Drug‐induced Pancreatitis
Making an etiological diagnosis of drug‐induced pancreatitis is difficult as it is a rare entity and other causes of pancreatitis should be ruled out before making the diagnosis. The duration between the exposure and the onset of pancreatitis is variable, suggesting idiosyncratic reaction in a majority of cases [43]. The diagnosis of drug‐induced pancreatitis should be considered in the presence of a temporal relationship with the offending drug (see Table 2.1), normal calcium and triglyceride levels, and in the absence of common etiologies (e.g. gallstone, alcohol abuse).
Other Etiological Diagnoses of Acute Pancreatitis
Hypercalcemia
This is an uncommon but treatable cause of AP. Hypercalcemia must be ruled out initially and again after recovery from AP as calcium levels may be lower during an acute attack of pancreatitis. The most common cause of hypercalcemia is hyperparathyroidism. Many patients may have an elevated level of parathyroid hormone but vitamin D deficiency should be excluded before diagnosing hyperparathyroidism.
Hypertriglyceridemia
Hypertriglyceridemia (HTG) is another uncommon but important metabolic cause of AP. Serum triglyceride levels above 1000 mg/dl can cause pancreatitis. Even lower levels may be associated with a higher risk of AP. The mechanism of pancreatitis due to HTG is not fully understood. Most patients with severe HTG have an underlying familial disorder of lipid metabolism, which needs further evaluation. Since only some patients with HTG develop AP, a cofactor may be required to cause pancreatitis. A higher frequency of CFTR mutations has been reported in HTG‐induced pancreatitis [44]. In alcoholic pancreatitis, serum triglyceride level can be elevated during an acute episode. Insulin with heparin and plasmapheresis have been shown to be beneficial in lowering lipid levels and improving the course of pancreatitis [45,46]. A newer therapy has been introduced in the form of an antisense molecule known as volanesorsen [47].
Smoking
Smoking increases the risk of AP. A Swedish population‐based study showed that the risk of non‐gallstone‐related pancreatitis was more than double in current smokers with more than 20 pack‐years than lifelong nonsmokers [relative risk 2.29, 95% confidence interval (CI) 1.63–3.22]. Among alcoholics consuming more than 400 g/month of alcohol, the risk of developing pancreatitis was fourfold higher in smokers than in lifelong nonsmokers [48]. Former smokers were also at increased risk of AP as shown in a meta‐analysis [49]. The risk of AP decreased to normal (similar to the nonsmoking population) after at least two decades of smoking cessation [48].
Type 2 Diabetes Mellitus
In a retrospective cohort study, patients with type 2 diabetes had a 2.83‐fold (95% CI 2.61–3.06) increased risk of AP and a 1.91‐fold (95% CI 1.84–1.99) greater risk of biliary disease [50]. This finding has been confirmed in other studies [51,52]. Patients taking antidiabetic drugs have a reduced risk of AP and the adjusted hazard ratio decreases to 0.31 from 1.89 [53].
Pancreatobiliary Tumors
Pancreatobiliary tumors are an uncommon etiology but should be considered in patients older than 50 years who present with no identifiable cause of AP. Both benign and malignant lesions, such as periampullary tumor, pancreatic adenocarcinoma, neuroendocrine tumor, and intraductal pancreatic mucinous neoplasm, can present with pancreatitis in 2–7% of patients [54]. These tumors can be diagnosed by CT, magnetic resonance imaging (MRI) and/or EUS. For small tumors, EUS is better than cross‐sectional imaging [55].
Post‐ERCP Pancreatitis
AP is the most common complication of ERCP. Transient hyperamylasemia occurs in up to 75% of patients after ERCP without abdominal pain. Hence, AP should be considered in patients with clinical evidence of pancreatitis in the presence of elevated (at least three times the upper limit of normal) serum amylase/lipase level at 24 hours post ERCP and requiring admission or prolongation of planned admission to two to three days [56]. Based on this definition, the incidence of post‐ERCP pancreatitis is 3–10% in systematic reviews [57–59]. A four‐ or six‐hour amylase/lipase level of more than four to five times the upper limit of normal can also predict post‐ERCP pancreatitis with high sensitivity and specificity [60]. Perforation is an important differential diagnosis and there should be a low threshold to perform abdominal CT with oral contrast if there is a suspicion of perforation as a differential diagnosis as it is the most sensitive and specific test [61,62].
Independent patient‐ and procedure‐related risk factors act synergistically in post‐ERCP pancreatitis (Table 2.3).
Single and Double Balloon Enteroscopy
Single‐ and double‐balloon enteroscopy may cause hyperamylasemia in 16–17% of patients and may be due to stretch and friction of proximal intestine. However, clinical AP occurs in a small fraction (0.7%) of patients who undergo balloon enteroscopy [64,65].
Congenital Anomalies
Pancreas Divisum
This is the most common congenital anomaly of the pancreas and is seen in 5–14% of the general population. Pancreas divisum has long been associated with pancreatitis but the causality is suspect. In a large series of patients undergoing ERCP, there was no difference in the prevalence of pancreas divisum in the groups with and without pancreatitis [66]. In patients with idiopathic recurrent acute pancreatitis and pancreas divisum, genetic polymorphism/mutation in serine protease inhibitor Kazal type 1 (SPINK1) and cystic fibrosis transmembrane conductance regulator (CFTR) genes have been shown as important cofactors [67]. A randomized controlled trial (SHARP) is currently being conducted to evaluate the efficacy of minor papilla sphincterotomy in patients with recurrent AP and pancreas divisum.
Table 2.3 Independent risk factors for post‐ERCP pancreatitis.
Source : adapted from Dumonceau et al. [63].
| Odds ratio (95% confidence interval) | |
|---|---|
| Patient‐related risk factors | |
| Prior post‐ERCP pancreatitis | 8.7 (3.2–23.8) |
| Female sex | 3.5 (1.1–10.6) |
| Previous recurrent pancreatitis | 2.5 (1.9–3.1) |
| Suspected sphincter of Oddi dysfunction | 1.9 (1.4–2.6) |
| Younger patient age (<40 years old) | 1.8 (1.3–2.6) |
| Absence of chronic pancreatitis |
1.9 (1–3.48)
|