Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal. Читать онлайн. Newlib. NEWLIB.NET

Автор: Tamilvanan Shunmugaperumal
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119585251
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Linear term A 7.61 0.0202 1.09 0.3219 0.0013 0.9714 B 1.14 0.3111 0.5629 0.4704 0.9391 0.3554 C 3.32 0.0986 9.47 0.0117 4.11 0.0702 Interaction term AB 0.2709 0.6141 0.0928 0.7668 2.11 0.1769 AC 4.36 0.0633 3.46 0.0924 0.3590 0.5624 BC 0.1542 0.7028 2.01 0.1872 1.83 0.2054 Quadratic term A 2 0.1161 0.7403 0.0911 0.7689 0.0981 0.7605 B 2 6.89 0.0254 0.0157 0.9027 0.3624 0.5606 C 2 4.08 0.0711 5.99 0.0344 2.69 0.1317

      Note: A/a: Castor oil, B/b: Chitosan, C/c: Poloxamer.

      The coefficient significance of the quadratic polynomial models was evaluated by using Analysis of Variance (ANOVA). For any of the terms in the models, a large F‐value and a small p‐value indicated more significant effect on the respective response variables (Joglekar 1987). Table 2.8 shows the effect of independent variables on the variation of the physicochemical properties of topical ophthalmic emulsions. The variable that exhibited the largest and significant (p < 0.05) effect on the MPS of the emulsion for the linear term was castor oil amount. The other two variables (amounts of chitosan and poloxamer) showed insignificant effects. All the interaction terms showed insignificant effect on MPS. The quadratic terms of chitosan amount exhibited significant effect on MPS while other two terms showed insignificant effect.

      The independent variables that most affect the ZP value of the emulsions for the linear term were poloxamer amount followed by the linear term of chitosan amount and castor oil amount but none of the linear terms has any significant effect. All the three interaction and quadratic effects have insignificant effect (p > 0.05) on the ZP value of the emulsions.

      For the PDI, the linear and quadratic terms of poloxamer amount have the significant effect while all other linear, interaction, and quadratic terms have insignificant effect. Thus, it was indicated that in evaluating the response variation of PDI, it was important to consider the poloxamer amount.

       2.5.1.6. Response Surface Plot Analysis

Schematic illustrations of the response surface plots showing the interaction effects of castor oil and chitosan (a, d, g), castor oil and poloxamer (b, e, h), and chitosan and poloxamer (c, f, i) on response, mean particle size (R1), polydispersity index (R2), and zeta potential (R3), respectively.

      The PDI value is ranged from 0 to 1 wherein PDI < 0.1 indicates a nearly homogenous monodisperse formulation. The PDI value between 0.1 and 0.2 specifies a particle population with relatively