Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal. Читать онлайн. Newlib. NEWLIB.NET

Автор: Tamilvanan Shunmugaperumal
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119585251
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the FMEA analysis allows the information on risk to be stored for future use. In this manner, it is important for the larger organization in which the turnover results in the loss of institutional memory. The outcomes of FMEA analysis are to define the RPN and further computation of RPN.

Critical Quality Attributes (CQAs) REM for Qualitative Analysis of Risk Assigned to
Volume of Castor Oil Amount of Chitosan Amount of Poloxamer 407 Premixing Time Homogenization Time Homogenization Speed Probe Sonication Time
Mean particle size High Medium Medium Medium High High Medium
Polydispersity index Low Low Medium Medium Medium High Medium
Zeta potential Low High Low Low Low Low Low
Failure Modes Detection (D) Occurrence (O) Severity (S) RPN (=DOS) Consequences on CQAs
Volume of castor oil (ml) 5 5 8 200 MPS
Amount of chitosan (mg) 6 5 7 210 MPS and ZP
Amount of poloxamer (mg) 5 5 5 125 MPS and PDI
Premixing time (min) 5 7 7 245 MPS and PDI
Homogenization time (min) 5 4 6 120 MPS and PDI
Homogenization speed (rpm) 5 6 7 210 MPS and PDI
Probe sonication time (min) 2 3 3 18 MPS and PDI
Schematic illustration of Ishikawa fish-bone diagram made with the help of Minitab 18 software showcasing the potential cause-effect relationship among the product and process variables for topical ocular emulsions.

       2.5.1.2. Factor Screening Study