Table of Contents
1 COVER
5 FOREWORD
6 PREFACE
7 CHAPTER 1: INTRODUCTION: AN OVERVIEW OF NANOSIZED EMULSIONS 1.1. INTRODUCTION 1.2. CONCLUSION REFERENCES
8 CHAPTER 2: FORMULATION DEVELOPMENT OF OIL‐IN‐WATER NANOSIZED EMULSIONS 2.1. INTRODUCTION 2.2. FDA‐APPROVED OILS, EMULSIFIERS, AND AUXILIARY OR MISCELLANEOUS EXCIPIENTS 2.3. CURRENT AND NEAR FUTURE DIRECTION 2.4. LIPOPHILIC API INCORPORATION PATTERN INTO NANOSIZED EMULSIONS 2.5. QbD APPROACH TO OPTIMIZE EMULSION 2.6. CONCLUSION REFERENCES
9 CHAPTER 3: CHARACTERIZATION AND SAFETY ASSESSMENT OF OIL‐IN‐WATER NANOSIZED EMULSIONS 3.1. INTRODUCTION 3.2. PHYSICAL AND VISUAL EVALUATIONS 3.3. CHEMICAL AND BIOLOGICAL EVALUATIONS 3.4. SAFETY AND EFFICACY ASSESSMENTS 3.5. CONCLUSION REFERENCES
10 CHAPTER 4: MANUFACTURING AND POSITIONING (GENERATIONS) OF OIL‐IN‐WATER NANOSIZED EMULSIONS 4.1. INTRODUCTION 4.2. GENERATIONS OF O/W NANOSIZED EMULSIONS 4.3. PREPARATION METHODS FOR API‐FREE/LOADED O/W NANOSIZED EMULSIONS 4.4. CONCLUSION REFERENCES
11 CHAPTER 5: BIOFATE OF NANOSIZED EMULSIONS 5.1. INTRODUCTION 5.2. BIOFATE OF O/W NANOSIZED EMULSIONS 5.3. CLINICAL ISSUES OF FIRST‐GENERATION NANOSIZED EMULSIONS 5.4. CONCLUSION REFERENCES
12 CHAPTER 6: MEDICAL OR THERAPEUTICAL APPLICATIONS OF OIL‐IN‐WATER NANOSIZED EMULSIONS 6.1. INTRODUCTION 6.2. MEDICAL OR THERAPEUTICAL APPLICATIONS OF O/W NANOSIZED EMULSIONS 6.3. CONCLUSION REFERENCES
13
PART I: OVERVIEW OF TOCOL‐BASED EMULSIONS, OXYGEN‐CARRYING EMULSIONS, EMULSIONS WITH DOUBLE OR TRIPLE CARGOS AND EMULSION‐LIKE DISPERSIONS
CHAPTER 7: OVERVIEW OF TOCOL‐BASED EMULSIONS, OXYGEN‐CARRYING EMULSIONS, EMULSIONS WITH DOUBLE OR TRIPLE CARGOS AND EMULSION‐LIKE DISPERSIONS
CHAPTER 7.1: TOCOL‐BASED NANOSIZED EMULSIONS
7.1.1. INTRODUCTION
7.1.2. FORMULATION DEVELOPMENT USING TOCOL
7.1.3. NON‐ AND PRE‐CLINICAL SAFETY STUDIES
7.1.4. THERAPEUTIC APPLICATIONS
7.1.5. CONCLUSION
REFERENCES
CHAPTER 7.2: OXYGEN‐CARRYING EMULSIONS
7.2.1. INTRODUCTION
7.2.2. RATIONALE FOR SELECTING PERFLUOROCARBON FOR IN VIVO OXYGEN TRANSPORT
7.2.3. FORMULATION OF STABLE INJECTABLE PERFLUOROCARBON EMULSIONS
7.2.4. MULTIFUNCTIONAL PERFLUOROCARBON‐BASED EMULSIONS
7.2.5. GENERATIONS AND HURDLES OF PERFLUOROCARBON‐BASED NANOSIZED EMULSIONS AS OXYGEN CARRIERS
7.2.6. PROPOSED SOLUTIONS TO OVERCOME THE HURDLES OF PERFLUOROCARBON‐BASED NANOSIZED EMULSIONS USED AS OXYGEN CARRIERS
7.2.7. CONCLUSION
REFERENCES
CHAPTER 7.3: NANOSIZED EMULSIONS FOR MULTIPLE MEDICAMENT LOADINGS, IMAGING, AND THERANOSTIC PURPOSES
7.3.1. INTRODUCTION
7.3.2. BRIEF REVIEW OF RESEARCH REPORTS ON NANOSIZED EMULSIONS FOR IMAGING AND THERANOSTIC PURPOSE
7.3.3. VARIOUS TOPOLOGIES OBSERVED IN DISPERSED OIL DROPLETS OF THE EMULSIONS
7.3.4.