Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal. Читать онлайн. Newlib. NEWLIB.NET

Автор: Tamilvanan Shunmugaperumal
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119585251
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13 Axial 1.5 6 87.5 333.9 0.408 30.6 14 Center 1.5 12 87.5 609.8 0.655 27.2 15 Factorial 1 6 75 240.1 0.287 17.9 16 Factorial 1 6 100 447.6 0.676 15.6 17 Center 1.5 12 87.5 609.8 0.655 27.2 18 Factorial 1 18 100 453.4 0.62 25.1 19 Factorial 2 18 75 492.8 0.537 20.9 20 Center 1.5 12 87.5 609.8 0.655 27.2

      MPS, mean particle size; PDI, polydispersity index; ZP, zeta potential.

      Each row indicates an experiment while the columns present the composition and the critical quality attributes (CQAs) of the non‐phospholipid‐based topical ophthalmic emulsions.

Screened CMAs and CPPs Quantity Levels
Low High
X 1: Castor oil (ml) 1, 1.5, 2 1 2
X 2: Chitosan (mg) 6, 12, 18 6 18
X 3: Poloxamer (mg) 75, 87.5, 100 75 100
CsA (% w/w) 0.05 or 0.1
Glycerin (g) 2.25
Double distilled water (ml) Upto 100
Selected CQAs Goal
R 1 : Mean particle size Minimize
R 2 : Polydispersity index Minimize
R 3 : Zeta potential Maximize

      Note: Italics numbers and texts indicate constant quantity of independent variables while the quantity of other independent variables were altered.

       2.5.1.5. Systematic Optimization Using Face‐Centered CCD