Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal. Читать онлайн. Newlib. NEWLIB.NET

Автор: Tamilvanan Shunmugaperumal
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119585251
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(in general, aii), and a12, a13, and a23 (in general, aij), respectively.


e-mail: [email protected]

CQAs Model Equations R 2 Adjusted R2
Mean particle size (R1) Coded: R1= 569.86 + 65.20 × A + 25.21 × B + 43.03 × C + 13.75 × AB − 55.18 × AC − 10.38 × BC + 15.35 × A2 − 118.30 × B2 − 91.00 × C2 0.8186 0.6553
Actual: PS = −5992.56500 + 663.59545 × a + 88.29447 × b + 120.25931 × c + 4.58333 × a × b − 8.82800 × a × c − 0.138333 × b × c + 61.41818 × a2 − 3.28598 × b2 − 0.582371 × c2
Polydispersity index (R2) Coded: R2 = 0.6038 + 0.0325 × A + 0.0234 × B + 0.0960 × C − 0.0106 × AB − 0.0649 × AC − 0.0494 × BC + 0.0180 × A2 + 0.0075 × B2 + 0.1455 × C2 0.7188 0.4658
Actual: PDI = −9.27017 + 0.800295 × a + 0.061847 × b +0.194161 × c −0.003542 × a × b − 0.010380 × a × c − 0.000658 × b × c + 0.071818 × a2 + 0.000207 × b2 − 0.000931 × c2
Zeta potential (R3) Coded: R3 = 28.89 + 0.0500 × A + 1.32 × B − 2.76 × C − 2.21 × AB − 0.9125 × AC + 2.06 × BC − 0.8136 × A2 − 1.56 × B2 − 4.26 × C2 0.6525 0.3397
Actual: ZP = −180.64250 + 31.48864 × a − 0.037576 × b + 4.44347 × c − 0.737500 × a × b − 0.146000 × a × c + 0.027500 × b × c − 3.25455 × a2 − 0.043434 × b2 − 0.027287 × c2
CCD effects Variables R 1 R 2 R 3
F‐value P‐value F‐value P‐value F‐value P‐value