Principles of Virology. Jane Flint

12Figure 12.1 Localization of viral proteins to the nucleus. The nucleus and maj...Figure 12.2 Localization of viral proteins to the plasma membrane. Viral envel...Figure 12.3 Primary sequence features and covalent modifications of the influenz...Figure 12.4 Maturation of influenza virus HA0 protein during transit along the s...Figure 12.5 The endoplasmic reticulum. (A) The ER of a mammalian cell in cultu...Figure 12.6 Canonical targeting of a nascent protein to the ER membrane. Trans...Figure 12.7 Detection and synthesis of N-linked oligosaccharides. (A) Detectio...Figure 12.8 Integration of folding and glycosylation in the ER. (A) The model ...Figure 12.9 Folding of the two Sindbis virus envelope proteins depends on format...Figure 12.10 Compartments in the secretory pathway. Proteins destined for secr...Figure 12.11 Protein transport from the ER to the Golgi apparatus. (A) Protein...Figure 12.12 Low-pH-induced conformational change and maturation of dengue virus...Figure 12.13 Polarized epithelial cells and neurons. (A) Tight junctions block...Figure 12.14 Axonal transport of herpesviral particles in neurons. (A) At the ...Figure 12.15 Modulation of the unfolded protein response in virus-infected cells...Figure 12.16 Addition of lipids to cytoplasmic proteins. (A) N-terminal myrist...Figure 12.17 Targeting signals of human immunodeficiency virus type 1 Gag protei...Figure 12.18 Targeting signals of matrix proteins of influenza virus (A) and ves...Figure 12.19 Sorting of viral glycoproteins to internal cell membranes. The de...Figure 12.20 Transport of influenza A virus genomic RNA segments from the nucleu...Figure 12.21 Models of the rhabdovirus nucleocapsid, showing the free nucleocaps...Figure 12.22 Cytoplasmic trafficking of retroviral genomes with different nuclea...

      13 Chapter 13Figure 13.1 Pathways of virus particle assembly and release. The structural un...Figure 13.2 Examination of virus assembly by high-resolution microscopy. Incre...Figure 13.3 Mechanisms of assembly of viral structural units. (A) Assembly fro...Figure 13.4 Radial organization of the Gag polyprotein in immature human immunod...Figure 13.5 Some assembly reactions assisted by cellular chaperones. (A) The E...Figure 13.6 Assembly of poliovirus in the cytoplasm of an infected cell. (A) M...Figure 13.7 Formation of bullet-shaped particles by the vesicular stomatitis vir...Figure 13.8 Assembly of herpes simplex virus 1 nucleocapsids. (A) Assembly beg...Figure 13.9 Assembly of influenza A virus. Assembly proceeds in stepwise fashi...Figure 13.10 Assembly of a retrovirus from polyprotein precursors. The Gag pol...Figure 13.11 Viral DNA-packaging signals. (A) Human adenovirus type 5 (Ad5). T...Figure 13.12 Packaging of herpes simplex virus 1 DNA. (A) Organization of the ...Figure 13.13 Sequences important for the packaging of retroviral genomes. (A) ...Figure 13.14 Organization of ribonucleoproteins in influenza A virus particles. ...Figure 13.15 Interaction of viral proteins responsible for budding at the plasma...Figure 13.16 L domains and release of retroviral particles. (A) Electron micro...Figure 13.17 Functions of the ESCRT pathway in uninfected and virus-infected cel...Figure 13.18 Model of hepatitis B virus envelopment. The pregenome RNA synthes...Figure 13.19 Vaccinia virus assembly and exocytosis. Viral structures observed...Figure 13.20 Movement of vaccinia virus on actin tails. (A) Immunofluorescence...Figure 13.21 Pathway of herpesvirus egress. The mature nucleocapsid assembled ...Figure 13.22 Disruption of the nuclear lamina in herpes simplex virus 1-infected...Figure 13.23 Models for nonlytic release of picornavirus particles. (A) Synthe...Figure 13.24 Morphological rearrangement of retrovirus particles upon proteolyti...Figure 13.25 Model for refolding of the human immunodeficiency virus type 1 CA p...Figure 13.26: The maturation of hepatitis B virus particles. (A) Alternative t...Figure 13.27 Direct cell-to-cell spread of virus particles. (A) Human immunode...

      14 Chapter 14Figure 14.1 The mammalian PI3K-AKT-mTOR signaling route. The core features of ...Figure 14.2 Signaling via PI3K facilitates virus entry. Shown are three exampl...Figure 14.3 Common activation of the PI3K-AKT-mTOR relay in virus-infected cells...Figure 14.4 Inhibition of cellular gene expression by viral proteins. (Transcr...Figure 14.5 Decreases in cellular mRNA concentration in virus-infected cells. ...Figure 14.6 Polyribosome profiling. Shown is a comparison of the polyribosome ...Figure 14.7 Reprogramming of promoter-associated transcriptional regulators by a...Figure 14.8 Increased glycolysis in virus-infected cells. (A) Infection by a v...Figure 14.9 Glucose metabolism. Following transport into cells via glucose tra...Figure 14.10 Diversion of acetyl-CoA for fatty acid synthesis in human cytomegal...Figure 14.11 The citric acid cycle and some alterations induced in virus-infecte...Figure 14.12 The electron transport chain and oxidative phosphorylation. The e...Figure 14.13 Storage and mobilization of fatty acids. (A) Fatty acids are tran...Figure 14.14 Mechanisms of stimulation of fatty acid synthesis in human cytomega...Figure 14.15 Increased synthesis and accumulation of fatty acids in hepatitis C ...Figure 14.16 Increased import of fatty acids into poliovirus-infected cells. (...Figure 14.17 Reorganization of nuclei in polyomavirus-infected cells. Murine 3...Figure 14.18 Example of a PML-containing nuclear structure in DNA virus-infected...Figure 14.19 Reorganization of nuclear splicing components in DNA virus-infected...Figure 14.20 Dengue virus cytoplasmic replication and assembly organelles. Hum...Figure 14.21 Hepatitis C virus replication and assembly compartments. (A) The ...Figure 14.22 Cooption of cytoplasmic membranes and lipid droplets in poliovirus-...Figure 14.23 Initial rotavirus assembly on lipid droplets. (A) The kinetics of...

      15 AppendixFigure 1 Structure and genome organization of human adenovirus type 5. (A) Vir...Figure 2 Infectious cycle of human adenovirus type 5. (1) The virus attaches t...Figure 3 Structure and genome organization. (A) Virus particle structure. Cryo...Figure 4 Infectious cycle. (1, 2) The virion binds to a cellular receptor, whi...Figure 5 Structure and genome organization of murine coronavirus. (A) Virus pa...Figure 6 Infectious cycle. (1) The virus particle binds to a cell surface rece...Figure 7 Structure and genome organization of the filovirus Zaire ebolavirus. Figure 8 Infectious cycle of ebolavirus. (1) Virus particles bind to a cell su...Figure 9 Structure and genome organization of flaviviruses. (A) Virus particle...Figure 10 Infectious cycle. (1) The virus particle binds to a cell surface rec...Figure 11 Structure and genome organization of orthohepadnaviruses. (A) Virus ...Figure 12 Infectious cycle of hepatitis B virus. (1) The virion attaches to a ...Figure 13 Structure and genome organization of alphaherpesviruses. (A) Virus p...Figure 14 Infectious cycle of herpes simplex virus type 1. (1) Virions bind to...Figure 15 Structure and genome organization of the orthomyxovirus influenza A vi...Figure 16 Infectious cycle of influenza A virus. (1) The virion binds to a sia...Figure 17 Structure and genome organization. (A) Virus particle structure. Ima...Figure 18 Infectious cycle. (1) The virion attaches by binding to specific rec...Figure 19 Structure and genome organization of adenovirus­associated virus (AAV)...Figure 20 Infectious cycle of adenovirus­associated virus (AAV). Heparan sulfa...Figure 21 Structure and genomic organization of poliovirus. (A) Virus particle...Figure 22 Infectious cycle of poliovirus. (1) The virion binds to a cellular r...Figure 23 Structure and genome organization of simian virus 40. (A) Virus part...Figure 24 Infectious cycle of simian virus 40. (1) The virus particle attaches...Figure 25 Structure and genome organization of the poxvirus vaccinia virus. (A...Figure 26 Infectious cycle of vaccinia virus. (1) After receptor binding and f...Figure 27 Structure and genomic organization of an orthoreovirus. (A) Virus pa...Figure 28 Infectious cycle of orthoreovirus. (1) The virion binds to cellular ...Figure 29 Structure and genomic organization. (A) Virus particle structure. Th...Figure 30 Infectious cycle of a retrovirus with a simple genome. (1) The virus...Figure 31 Structure and genomic organization of vesicular stomatitis virus. (A...Figure 32 Infectious cycle. (1) The virion binds to a cellular receptor, such ...Figure 33 Structure and genomic organization. (A) Virus particle structure. Th...Figure 34 Infectious cycle. (1) The virion binds to a cellular receptor and en...

      16 Chapter 1Figure 1.1 Conquerors of yellow fever. This painting by Dean Cornwell (1939) d...Figure 1.2 The pace of discovery of new infectious agents in the dawn of virol...Figure 1.3 Consequences of the 1918 influenza pandemic. (A) The 1918–19 influe...Figure 1.4 Deaths caused by the yellow fever epidemic in Philadelphia, 1793. T...Figure 1.5 Spread of West Nile virus in the United States. The maps show the s...Figure 1.6 Fruit bat geographic range in Southeast Asia, and prevalence of Nip...Figure 1.7 Ebola outbreak. Health care workers in areas of the Ebola virus out...Figure 1.8 Zika spread in Brazil. (A) In three short years, from 2014 to 2016,...Figure 1.9 Twitter as a tool in viral epidemiology. Between May 1 and December...Figure 1.10 Seasonal variation in disease caused by three human pathogens in t...

      17 Chapter 2Figure 2.1 Ectromelia virus infection of mice. Infection begins with a break i...Figure 2.2 The coordinated host response to infection. In healthy individuals,...Figure 2.3 Infection seen as a series of bottlenecks.