Table of Contents
1 Cover
2
Volume I
Preface
What’s New
Principles Taught in Two Distinct, but Integrated Volumes
Acknowledgments
About the Authors
Key of Repetitive Elements
PART I: The Science of Virology
1 Foundations
Luria’s Credo
Viruses Defined
Why We Study Viruses
Virus Prehistory
Discovery of Viruses
The Defining Properties of Viruses
Cataloging Animal Viruses
A Common Strategy for Viral Propagation
Perspectives
References
2 The Infectious Cycle
Introduction
The Infectious Cycle
Viral Pathogenesis
Overcoming Host Defenses
Cultivation of Viruses
Assay of Viruses
Viral Reproduction: the Burst Concept
The One-Step Growth Cycle
Global Analysis
Single-Cell Virology
Perspectives
References
PART II: Molecular Biology
3 Genomes and Genetics
Introduction
Genome Principles and the Baltimore System
Structure and Complexity of Viral Genomes
What Do Viral Genomes Look Like?
Coding Strategies
What Can Viral Sequences Tell Us?
The “Big and Small” of Viral Genomes: Does Size Matter?
The Origin of Viral Genomes
Genetic Analysis of Viruses
Perspectives
References
4 Structure
Introduction
Building a Protective Coat
Packaging the Nucleic Acid Genome
Viruses with Envelopes
Large Viruses with Multiple Structural Elements
Other Components of Virions
Mechanical Properties of Virus Particles
Perspectives
References
5 Attachment and Entry
Introduction
Attachment of Virus Particles to Cells
Entry into Cells
Intracellular Trafficking and Uncoating
Import of Viral Genomes into the Nucleus
Perspectives
References
6 Synthesis of RNA from RNA Templates
Introduction
The Nature of the RNA Template
The RNA Synthesis Machinery
Mechanisms of RNA Synthesis
Paradigms for Viral RNA Synthesis
Origins of Diversity in RNA Virus Genomes
Perspectives
References
7 Synthesis of RNA from DNA Templates
Introduction
Transcription by RNA Polymerase II
Transcription of Viral DNA Templates by the Cellular Machinery Alone
Viral Proteins That Govern Transcription of DNA Templates
Transcription