Clinical Pancreatology for Practising Gastroenterologists and Surgeons. Группа авторов

Pancreas in Cystic Fibrosis and CFTR‐related Disorders Pathogenesis of CFTR‐related Pancreatitis Pancreatic cystosis CFTR‐modifying Therapies Conclusion References 48 Nutritional Therapy, Pancreatic Exocrine Insufficiency, and Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis Introduction Mechanisms of Pancreatic Exocrine Insufficiency Diagnosis of Pancreatic Exocrine Insufficiency Nutritional Consequences and Treatment of Pancreatic Exocrine Insufficiency Follow‐up Care of Patients with Pancreatic Exocrine Insufficiency Future of CF Nutrition Care References

      12  Section V: Pancreatic Cancer 49 Epidemiological Impact of Pancreatic Cancer Current Burden of Pancreatic Cancer Time Trends Risk Factors for Pancreatic Cancer Attributable Fraction of Pancreatic Cancer due to Potentially Modifiable Risk Factors Future Burden of Pancreatic Cancer Conclusion References 50 Molecular and Genetic Basis of Pancreatic Carcinogenesis Introduction Individual Therapy Based on the Genomic and Transcriptomic Traits of Pancreatic Cancer Organoids for Response Prediction Enhancing the Activation of Immune Surveillance and Inhibition of Immune Suppression Exploiting the Metabolic Alterations in Pancreatic Cancer Cells Targeting the Tumor Stroma Summary References 51 New‐onset Diabetes as a Harbinger of Pancreatic Cancer: is Early Diagnosis Possible? Introduction Epidemiology of DM in PDAC Using NOD for Early Detection of PDAC Methods to Enrich the NOD Cohort to Screen for PDAC Current Research Endeavors Conclusions and Recommendations to Practitioners Acknowledgments References 52 Pancreatic Cancer Screening Introduction Target Populations Screening Modality Screening Protocol Outcomes of Screening and Surveillance Programs Cost‐effectiveness of Pancreatic Cancer Screening Programs Conclusion Acknowledgments References 53 Clinical Usefulness of Biological Markers in Pancreatic Cancer Introduction Challenges in Early Detection of Pancreatic Cancer Role of Clinically Established Biomarkers of Pancreatic Cancer Early Cancer Detection by Novel Biomarkers Summary References 54 Staging Classification and Stratification of Pancreatic Cancer for Clinical Practice Introduction Clinical Staging Clinically Relevant Molecular Features Imaging Classification of Non‐metastatic Disease Imaging for Staging Evaluating Response to Neoadjuvant Therapy Future Directions Acknowledgments References 55 Imaging Diagnosis and Staging of Pancreatic Cancer Introduction CT Technique Anatomy Pancreatic Adenocarcinoma Conclusion References 56

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