Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting. Tamilvanan Shunmugaperumal. Читать онлайн. Newlib. NEWLIB.NET

Автор: Tamilvanan Shunmugaperumal
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119585251
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      Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India

      1  2.1. Introduction

      2  2.2. FDA‐approved oils, emulsifiers, and auxiliary or miscellaneous excipients 2.2.1. Issues related to oil selection to make the o/w nanosized emulsions for medical application 2.2.2. Issues related to emulsifiers selection to stabilize the o/w nanosized emulsions for medical application 2.2.3. Importance of charge‐stabilized nanosized emulsions 2.2.4. Importance of neutral‐charged (sterically‐stabilized) nanosized emulsions 2.2.5. Advantages of nanosized emulsions stabilized by mixed or multicomponent emulsifier molecules 2.2.6. ‘Stealth’ property of nanosized emulsions: in vitro demonstrations 2.2.7. Advantages of stabilizers in nanosized emulsions 2.2.8. Miscellaneous additives

      3  2.3. Current and near future direction 2.3.1. Colloidal particles‐stabilized emulsions

      4  2.4 Lipophilic API incorporation pattern into nanosized emulsions 2.4.1. Extemporaneous API Addition 2.4.2. De Novo Emulsion Preparation 2.4.3. Interfacial Incorporation Approach 2.4.4. Incorporation of Antibodies, DNA Protein, Oligonucleotide, or Heat Labile Molecules

      5  2.5 QbD approach to optimize emulsion 2.5.1. Case study for optimizing systematically a formula to make o/w nanosized Emulsions

      6  2.6. Conclusion References

      EXPANSION OF ABBREVIATIONS

      Therapeutically, the oil‐in‐water (o/w) nanosized emulsions are used mainly as delivery carriers for lipophilic active pharmaceutical ingredient (API) molecules that show pharmacological activities after administration via parenteral, ocular, and transdermal routes. Furthermore, the o/w nanosized emulsions having anionic, cationic, or neutral charged dispersed oil droplets can be made especially by changing the emulsifiers so that the first step of engineered droplet surfaces could be obtained to extract multifunctional activities. The second step of engineered droplet surfaces in emulsions usually attains by decorating the droplet surface with anchoring or homing moiety either by conjugation or simple adsorption reaction. By combining both the surface charge optimization and engineered droplet surfaces, the o/w nanosized emulsions are indeed in recent years useful for API delivery and/or targeting to otherwise inaccessible internal organs of the human body (Tamilvanan 2009).

      This chapter initially starts with the different excipients or ingredients used in the emulsion preparation followed by a short overview on the lipophilic APIs’ incorporation pattern into the o/w nanosized emulsions. One more important section included in this chapter is how to optimize a formula for ensuring a quality emulsion formulation. This section introduces a case study that shows the Quality by Design (QbD) approach applied onto the emulsions to optimize a formula during preformulation studies. The effect of the amount of new chemical entity