286 277
287 278
288 279
289 280
290 281
291 282
292 283
293 284
294 285
295 286
296 287
297 288
298 289
299 290
300 291
301 292
302 293
303 294
304 295
305 296
306 297
307 298
308 299
309 300
310 301
311 302
312 303
313 304
314 305
315 306
316 307
317 308
318 309
319 310
320 311
321 312
322 313
323 314
324 315
325 316
326 317
327 318
328 319
329 320
330 321
331 322
332 323
333 324
334 325
335 326
336 327
337 328
338 329
339 330
340 331
341 332
342 333
343 334
344 335
345 336
346 337
347 338
348 339
349 340
350 341
351 342
352 343
353 344
354 345
355 346
356 346
357 347
358 348
359 349
360 350
361 351
362 352
363 353
364 354
365 355
366 356
367 357
368 358
369 359
370 360
371 361
372 362
373 363
374 364
375 365
376 366
377 367
378 368
379 369
380 370
381 371
382 372
383 373
384 374
385 375
386 376
387 377
388 378
389 379
390 380
391 E1
Preface
The first edition of Metabolic Regulation: A Human Perspective appeared in 1996. (It was pink.) When the second edition was published (in green) in 2003, it seemed that a revolution was taking place in metabolism. Tissues that we always thought were ‘doing metabolism’ turned out to be secreting hormones, adipose tissue and leptin being the prime example. By 2010, when the third (blue) edition was published, there were yet more changes in our understanding of metabolism and its regulation. The regulation of gene expression by nutrients (including, for instance, the carbohydrate-response element binding protein) was much better understood than previously. The techniques of genetic manipulation had also increased our understanding of metabolic pathways. In 1996, nobody could have guessed that a mouse without the adipose tissue enzyme hormone-sensitive lipase would be viable, let alone relatively normal: that finding led to the discovery of another enzyme of fat mobilisation, adipose triglyceride lipase. Similar studies made us revise our ideas about other ‘well-established’ enzymes such as phosphoenolpyruvate carboxykinase. Now, in 2018, we see more radical developments in the field.