X-Ray Fluorescence in Biological Sciences. Группа авторов. Читать онлайн. Newlib. NEWLIB.NET

Автор: Группа авторов
Издательство: John Wiley & Sons Limited
Серия:
Жанр произведения: Химия
Год издания: 0
isbn: 9781119645580
Скачать книгу
a minimum background in the sample spectrum when arranged in this geometry [6]. However, in this geometry the X‐rays penetrate deep in to the sample/support up to a few micron level and interact with the atoms present in the sample, resulting in high scattered intensity and thereby high spectral background. In addition to this, the intensity of characteristic X‐rays of the analyte elements emitted from deeper layers are absorbed by the matrix elements when these X‐rays try to escape the sample. Another phenomenon may also occur where the elemental X‐ray lines of matrix elements with higher energies than the absorption edges of the analyte lines may get absorbed by the analyte and thereby can excite the analyte element to emit its characteristic X‐ray lines, thus producing a higher intensity of the analyte X‐ray line compared to that which would have been obtained by exciting the sample by the exciting X‐ray beam only. In the above two situations, the observed intensity of the analyte line shall be less or more, respectively, than the theoretical normal intensity of the analyte X‐ray line which should have been obtained by sole excitation of the exciting beam.

      In wavelength dispersive X‐ray fluorescence (WDXRF), unlike in EDXRF, the angle between the exciting X‐ray beam and sample as well as that between detectors and sample changes continuously and hence the background also changes. The background produced in WDXRF is always appreciably high. In addition, the distance between the sample and the detector is also larger in WDXRF (a few centimeters) compared to that in EDXRF (a few millimeters). This reduces the sensitivity of a WDXRF spectrometer, due to the attenuation of X‐ray intensity by air and spectrometer components, the crystal analyzer placed between the sample and the detector, and also due to the smaller solid angle subtended by the detector on the sample. These factors limit the applicability of XRF ‐ EDXRF as well as WDXRF, especially for those samples which contain trace levels of analyte (in a sub‐ppm level ) or where the sample amount available is less, e.g. forensic, precious, biological samples, etc. [7].

      4.4.1 Principles of TXRF

      As stated above, the idea of TXRF application for trace element analysis was first put forward by two Japanese scientists, Yoneda and Horiuchi. Since then this technique has found applications in newer and advanced areas of material characterization [9]. The principles of TXRF analysis are based on the following three fundamental instrumentation changes to tradtional EDXRF:

      1 In TXRF, the primary beam falls on the sample/support at an angle less than the critical angle which is <1° for almost all materials and depends on the energy of the X‐ray beam as well as density and atomic number (Z) of the reflector materials. This feature of TXRF ensures that the incident X‐rays do not penetrate deep into the sample supports and hence the scattered background is drastically reduced and leads to far better detection limits compared to conventional XRF.

      2 As the primary parallel incident X‐ray beam falls on the sample support at an angle less than the critical angle, the sample support has to be a flat polished surface so that a fixed angle below the critical angle of support can be maintained for the impinging beam to totally reflect from it. In this situation, if a thin film of the sample having thickness of a few nanometers is deposited on the intersection area of the incident and reflected beams, it will be excited by the incident as well as by the totally reflected beams from the support. This arrangement results in almost double excitation of the sample compared to that in EDXRF and thus, increases the intensity of fluorescent X‐rays compared to that in EDXRF by about two times.

      3 Since the glancing as well as the reflection angles are generally below one degree (very near to zero degree) the detector can be brought very close to the sample deposited on the support ensuring the angle between the incident X‐ray beam and the detector to be about 90°. This arrangement leads to 0–90° geometry of beam and detector, required for attaining a low background in XRF (here in TXRF).

      The above geometrical arrangement takes care of the problems, associated with EDXRF, which are responsible for higher (inferior) detection limits and provides excellent elemental detection limits in TXRF comparable with other trace determination techniques, e.g. ICP‐OES, ICP‐MS, etc. In addition, the sample thickness is very small (a few nm) and hence the matrix effects associated are also negligible [8–10].

      4.4.2 Theoretical Considerations

Schematic illustration of x-rays undergoing reflection and refraction. Schematic illustration of total reflection of X-rays on the sample support containing sample ( yellow colour).