Initially, the course of the PD therapy was unremarkable (as indicated by green symbols), but then red flag alerts appeared on the dashboard, attesting the occurrence of a major issue. Analysis of the cycle volume profiles showed recurrent prolonged drainage times. The patient was contacted for urgent clinical evaluation and radiological investigations. Catheter migration was quickly diagnosed and required laparoscopic repositioning after an unsuccessful attempt of conservative treatment using laxatives. Afterwards, red flags disappeared from the dashboard and cycle volumes profiles were unremarkable, indicating normal progress of PD therapy. Because catheter dysfunction represents a major cause of PD drop-out and permanent transfer to hemodialysis in the first 3–6 months of therapy [6, 7], its identification is of utmost importance; any tool potentially contributing to an earlier diagnosis is of value for clinicians.
Sharesource also provides monthly overview graphs giving a general impression about the course of PD therapy, which, in the case of the aforementioned patient, was uneventful after the surgical correction of catheter migration. However, a few months later, empty boxes (i.e., devoid of symbols) appeared in the monthly overview graph, documenting the occurrence of non-adherence, which is defined as the performance of less than 90% of prescribed therapy; its early recognition enabled the PD team to quickly address this important issue. Indeed, non-adherence has been proved to have a major negative impact on clinical outcomes, as it is strongly associated with technique failure, rate and length of hospitalization as well as peritonitis and death [8–10]. According to recent data, its prevalence is high and extremely variable in PD patients, ranging from 2.6 to 53% for dialysis procedures [11]; young patients seem to be particularly at risk [12], possibly because they are more socially and professionally active and therefore confronted with more logistic challenges. In this case, the Sharesource monthly graph was shared with the 23-year-old patient to start an open discussion about this sensitive subject. Because it was presented as a positive tool to improve her care instead of the reflection of her poor adherence, she was not offended and did not feel her privacy was disturbed by RPM. On the contrary, it helped her to realize that missed therapies happened more frequently than she thought. After thorough explanations about the aforementioned potential short- and long-term issues, non-adherence to PD therapy resolved and monthly overviews were unremarkable in the following months.
Among PD complications, peritonitis remains one of the most frequent and most feared by nephrologists, due to its major negative impact on technique survival and transfer to permanent hemodialysis [13], as well as being a described risk factor for the occurrence of the rare but potentially life-threatening encapsulating peritoneal sclerosis through modifications of the characteristics of the peritoneal membrane [14]. Based on the postulate that ultrafiltration (UF) decreases during an acute episode [15, 16], a Mexican study retrospectively analyzed data in 10 patients and found a significant drop in UF 24 h before the occurrence of symptoms and a subsequent diagnosis of peritonitis [17]. It could, therefore, be a hint to an imminent episode, although the practical implication of this observation (e.g., by setting alarm parameters) may be difficult partly due to inter- and intra-individual variability of daily UF.
Apart from early detection of clinically relevant issues, RPM in APD offers further practical advantages. Indeed, as it allows for both remote observation and alteration of therapy, the need for physically coming into the PD unit is markedly reduced, which is of particular interest, not only for patients with social, geographical or physical limitations raising organizational difficulties, but also for those desiring to spend their time more efficiently; however, because clinical evaluation and communication with the patient remain the keystones of good care, a regular in-person visit, classically on a monthly basis, should be maintained.
Although home-based treatment such as PD is a particularly attractive concept, notably for active patients who desire more flexibility and control or for populations with reduced mobility or hampered by other limitations, the remote nature of at-home dialysis and the fear of being left alone may generate anxiety and thus hold them back from adopting it. A RPM platform such as Sharesource, through its permanent access for PD teams to data about the performed therapy, may provide patients reassurance and more confidence in embracing this method by attenuating this feeling of being left in a “black hole” in comparison with standard in-center hemodialysis. This may also be true for clinicians, whose worries about potentially being unaware of issues occurring at home could represent an obstacle to the implementation of PD in the care of their ESRD patients.
Clinical follow-up can also be further improved by APD cycler-embedded RPM as it can provide daily important clinical data such as blood pressure and weight values, which can be entered before the PD therapy is initiated. It proved to be of great help for a patient who presented to the PD unit with significant weight gain over a period of a week, and was clinically fluid overloaded with leg edema up to the knees and pathologic pulmonary auscultation. The PD prescription was altered to optimize UF, and the patient was then asked to document his daily weight. In the following days, the PD team could verify that the weight went progressively back to its dry value and remained stable thereafter.
Because of a tendency for recurrent fluid overload over the months that followed, this patient’s PD therapy had to be regularly altered; remote prescription greatly facilitated patient management by sparing a lot of travel time. Moreover, the PD team did not hesitate to make minor changes to further optimize therapy, thereby leading to a real patient-tailored prescription.
An Italian retrospective case-control study recently examined the clinical utility of the implementation of RPM with the SHARESOURCE platform in the care of their APD patients [18]. They observed 37 RPM-APD patients, 16 incidents, and 21 prevalents switched from traditional APD (cyclers functioning with a card containing data of performed therapy and registered prescriptions). They documented the number of modifications in APD prescription over a period of 6 months before and after the switch, and separately analyzed incident and prevalent patients. They demonstrated significantly more changes in prescriptions in both incident and prevalent RPM-APD patients as well as less visits to the PD unit for the incident group. Moreover, over 50% of major modifications, defined as having clinical relevance in terms of depuration or UF (minor changes aimed at reducing alarms) were done proactively in the incident group (42% in the prevalent group), that is, before a patient calling or presenting to the clinic. In summary, the major advantages of RPM documented in this study are: a more proactive type of care as well as a more personalized therapy, and a potential reduction in costs, at least for incident patients.
In summary, PD, and especially APD, is a medical field in which the broader use of RPM may be of particular benefit. The newly available cloud-based platform, Sharesource, has been implemented in recent years in the care of many patients throughout Europe, initially in England and Switzerland then in Italy and most recently in France. Through accurate monitoring of therapy and remote altering of prescription, RPM allows PD teams to work in a more proactive manner as compared with standard APD as well as to prioritize patients with red flags