Recent Advances in the Pathogenesis and Treatment of Kidney Diseases. Группа авторов. Читать онлайн. Newlib. NEWLIB.NET

Автор: Группа авторов
Издательство: Ingram
Серия: Contributions to Nephrology
Жанр произведения: Медицина
Год издания: 0
isbn: 9783318063509
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      New Intracellular Trafficking Pathway of Albumin through Glomerular Endothelial and Epithelial Cells

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      Conclusions

      In this report, we reviewed the new pathway by which albumin travels through caveolae in both glomerular endothelial and epithelial cells. This caveolae-dependent pathway appears to match several aspects of pathophysiology in glomerulonephritis, including the narrowing of fenestra in glomerular endothelial cells and the fusion of foot processes in podocytes. We suspect that this new theory may become part of the general etiology of albuminuria along with the fenestral pathway and the slit membrane pathway.

      Acknowledgements

      We thank Ryan Chastain-Gross, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

      References

      7Quest AF, Leyton L, Párraga M: Caveolins, caveolae, and lipid rafts in cellular transport, signaling, and disease. Biochem Cell Biol 2004;82:129–144.

      8Qin L, Zhu N, Ao BX, Liu C, Shi YN, Du K, Chen JX, Zheng XL, Liao DF: Caveolae and caveolin-1 integrate reverse cholesterol transport and inflammation in atherosclerosis. Int J Mol Sci 2016;17:429.