Principles of Virology. Jane Flint

of Viral Genes by RNA Polymerase III Inhibition of the Cellular Transcriptional Machinery Unusual Functions of Cellular Transcription Components in Virus-Infected Cells Viral DNA-Dependent RNA Polymerases Perspectives References 8 Processing Introduction Covalent Modification during Viral Pre-mRNA Processing Export of RNAs from the Nucleus Posttranscriptional Regulation of Viral or Cellular Gene Expression by Viral Proteins Regulation of Turnover of Viral and Cellular mRNAs in the Cytoplasm Noncoding RNAs Perspectives References 9 Replication of DNA Genomes Introduction DNA Synthesis by the Cellular Replication Machinery Mechanisms of Viral DNA Synthesis Exponential Accumulation of Viral Genomes Limited Replication of Viral DNA Genomes Origins of Genetic Diversity in DNA Viruses Perspectives References 10 Reverse Transcription and Integration Retroviral Reverse Transcription Retroviral DNA Integration Hepadnaviral Reverse Transcription Perspectives References 11 Protein Synthesis Introduction Mechanisms of Eukaryotic Protein Synthesis The Diversity of Viral Translation Strategies Regulation of Translation during Viral Infection Perspectives References 12 Intracellular Trafficking Introduction Assembly within the Nucleus Assembly at the Plasma Membrane Interactions with Internal Cellular Membranes Transport of Viral Genomes to Assembly Sites Perspectives References 13 Assembly, Release, and Maturation Introduction Methods of Studying Virus Assembly and Egress Assembly of Protein Shells Selective Packaging of the Viral Genome and Other Components of Virus Particles Acquisition of an Envelope Release of Virus Particles Maturation of Progeny Virus Particles Cell-to-Cell Spread Perspectives References 14 The Infected Cell Introduction Signal Transduction Gene Expression Metabolism Remodeling of Cellular Organelles Perspectives References APPENDIX: Structure, Genome Organization, and Infectious Cycles of Viruses Featured in This Book Adenoviruses Arenaviruses Coronaviruses Filoviruses Flaviviruses Hepadnaviruses Herpesviruses Orthomyxoviruses Paramyxoviruses Parvoviruses Picornaviruses Polyomaviruses Poxviruses Reoviruses Retroviruses Rhabdoviruses