9 4 New Psychoactive Substances 4.1 Overview of New Psychoactive Substances 4.1.1 Properties 4.1.2 NPS Market, Dynamics and International Control 4.1.3 Potential Metabolites and/or Transformation Products 4.1.4 Occurrence in the Environment 4.2 Sample Preparation and Collection 4.2.1 Urban Wastewater 4.2.1.1 Protocols for Collecting and Preparing Samples 4.2.1.2 Extraction Procedures and Clean-up 4.2.2 Other Environmental Matrices 4.3 Determination of New Psychoactive Substances 4.3.1 Development of the Instrumental Method 4.3.1.1 Chromatographic Separation 4.3.1.2 Detection 4.3.2 Figures of Merit 4.3.3 Hits and Tips 4.4 Future Direction and Challenges Acknowledgments References
10 5 Artificial Sweeteners 5.1 Overview of Artificial Sweeteners 5.1.1 Properties 5.1.2 Legislation and Environmental Risk Assessment 5.1.3 Reported or Potential Metabolites and/or Transformation Products 5.1.4 Occurrence in the Environment 5.2 Sample Preparation and Collection 5.2.1 Protocols for Collecting and Preparing Samples 5.2.2 Sample Extraction and Clean-up 5.3 Determination of Artificial Sweeteners 5.3.1 Development of the Instrumental Method 5.3.1.1 Chromatography 5.3.1.2 Detection 5.3.2 Figures of Merit 5.3.3 Hints and Tips 5.4 Future Directions and Challenges References
11 6 Perfluorinated Substances 6.1 Overview of Perfluoroalkyl Substances 6.1.1 Properties 6.1.2 Legislation 6.1.3 Reported or Potential Metabolites and/or Transformation Products 6.1.4 Occurrence in the Environment 6.2 Sample Preparation and Collection 6.2.1 Protocols for Collecting and Preparing Samples 6.2.2 Sample Extraction and Clean-up 6.3 Determination of PFASs 6.3.1 Development of the Instrumental Method 6.3.1.1 Chromatography-Mass Spectrometry 6.3.1.2 Biosensors 6.3.2 Figures of Merit 6.3.3 Hints and Tips 6.4 Future Directions and Challenges References
12 7 High Production Volume Chemicals 7.1 Overview of High Production Volume Chemicals 7.1.1 Properties 7.1.2 Legislation 7.1.3 Reported or Potential Metabolites and/or Transformation Products 7.1.4 Occurrence 7.2