Molecular Imaging. Markus Rudin. Читать онлайн. Newlib. NEWLIB.NET

Автор: Markus Rudin
Издательство: Ingram
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Жанр произведения: Медицина
Год издания: 0
isbn: 9781786346865
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Polarization, Reactants Model

      At this point, a brief reminder on molecular polarization is in order.

      The relaxation times are of the order of 10−15 sec for electronic polarization, 10−13 sec for the atomic and 10−11 sec or slower for orientational polarization [26].

      where θ is the angle between the direction of the electric field E of the ion and that of the molecular dipole p. The ion–dipole system is in electrical equilibrium when θ = 0, that is, when the dipole is lined up with the field. In this case, the direction of the dipole is the one dictated by the electric field and U is at its minimum value.

      When a molecule is in a medium, the orienting effect of the electric field is counteracted by the thermal agitation of the molecules, by their mutual interactions and orientation correlation of neighboring molecules [29] so that at temperature T the average equilibrium θ of the solvation molecules in the ion’s field may be different from zero. Moreover—and this fact is of paramount importance for the ET theory—the instantaneous polarization continuously fluctuates around its equilibrium value because of thermal agitation, a situation reminiscent of the vibrations of a harmonic oscillator around its equilibrium geometry.

      In the first model used by Marcus for the reacting ions, they are supposed to be spheres of radii a1 and a2. The spheres are rigid, formed by the bare ions and possibly by a spherical region of saturated dielectric made up by solvent molecules fully oriented in the ions’ fields. Outside these saturated spheres are the molecules whose Pu polarization is determined, as described above, by the counteracting ordering and disordering effects of electric fields and thermal agitation.

      Initially, under the influence of Born’s description of the charging of ions in solution, M. considered the spheres as conducting. This restrictive hypothesis was dropped later on.

       1.3.Solvation Molecules’ Contribution to the Barrier in ET Reactions

      In order to understand—on a qualitative level—the barrier to ET reactions due to the orientation of the solvent molecules around the ions, let us first consider the barrier to reaction for the most simple threecenter atom transfer reaction involving a linear activated complex, that is the H exchange reaction:

      The energy barrier to reaction is due to the fact that an activation energy is necessary to go from the reagents to the products because a chemical bond between two hydrogen atoms is to be broken while another one forms. If we imagine, for simplicity, that the reaction happens on a line, we may represent schematically the process as:

      where R stands for the reagents, P for the products and the double dagger symbol “‡” for the transition state at the nuclear configuration intermediate between that for R and P.

      Fig. 3.

      In