Molecular Imaging. Markus Rudin. Читать онлайн. Newlib. NEWLIB.NET

Автор: Markus Rudin
Издательство: Ingram
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Жанр произведения: Медицина
Год издания: 0
isbn: 9781786346865
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Company Ltd, (1967).

       CHAPTER 2

       Foundations of the Theory, Its First Formulation

       2.1.The Reaction Scheme for Bimolecular ET Reactions

      The reverse step of Eq. (2.3) is not considered because we are interested in calculating the rate constant of the overall forward reaction and, moreover, the concentration of the products, starting from a very dilute solution of reactants, would be very low.

      The process relative to the constant k−1 corresponds to the probability of “a disorganizing motion of the solvent, destroying the polarization appropriate to the intermediate state” so leading to deactivation. Likewise, X can go back to X and so a rate constant k−2 must be considered. Because of the small electronic interaction that was supposed to exist between reactants, the XX process can be slow and is the reason why two electronic structures of the TS were considered.

      Note that A and B are not necessarily the actual compounds introduced in the reaction system, they may rather be “active entities formed from them” (M.).

      The overall rate constant of the reaction sequence is kbicacb where the c’s denote concentrations and kbi is the observed bimolecular rate constant. According to Eq. (2.3), the rate is also given by k3cx, so that:

      The steady-state equations [37] for the concentrations of X and X are given by Eqs. (2.5) and (2.6):

      The meaning of Eq. (2.5) (standard chemical kinetics. . .) is the following: if during the reaction the concentration of X remains constant, this means that the effect of the two reactions leading to formation of X, with velocities k1cacb and k−2cx is equal to the effect of the reactions leading to depletion of it with velocities image and image The same argument is valid for Eq. (2.6). The two equations allow for the determination of those values of image and cx for which the conditions image and dcx/dt = 0 are valid.

      Introducing the value obtained for cx in Eq. (2.4), Eq. (2.7) is obtained [1]:

      M. has shown that when the probability of forming X from X is ≥ than the probability of X reforming A and B, then

image

      In an impressive tour de force, M. estimated in his landmark paper [1] all of the rate constants appearing in Eq. (2.7). The description of their calculation is the main purpose of this chapter.

       2.2.A Model for