Master of the Milanese, Francis I. returned to France and beheld his alliance courted by all the powers of Europe, when suddenly the death of the Emperor Maximilian (15th January 1519) proved a brand of discord. Francis and Charles were the only serious candidates for the vacant dignity. Guise, with a secret view, perhaps, to the crown of Jerusalem for himself, strained every nerve, exerted all his influence, on behalf of the French King. But Charles, the more skilful intriguer, prevailed; and Francis, deeply wounded and humiliated by his failure, revolved in his mind projects of war. In these the king did not lose sight of the great assistance he might expect from Guise, brave, skilful, and prudent as he was; and the esteem in which the young chief was held at court increased so greatly, that the French nobles came to consider him almost the equal of the members of the royal family. Guise, on the other hand, by reason of his enormous fortune and high birth, and in his quality of a foreign prince, spared no effort to place himself on the footing of an ally rather than of a subject of the King of France.
Pretexts for hostilities were not wanting; and soon we find Guise, at the head of his lansquenets, fighting victoriously over the very same ground upon which, in our day, French armies contended with very different results. Maya, Fontarabia, and the banks of the Bidassoa witnessed his prowess; he himself, a half-pike in his hand, led his men through the river, with water to his armpits, dislodging the enemy by the mere terror his audacity inspired. When he returned to Compiègne, where the court then was, the King hurried forth from his chamber to meet him, embraced him warmly, and gaily said, "that it was but fair he should go out to meet his old friend, who, on his part, always made such haste to meet and revenge him on his enemies." His summer triumphs in the Pyrenees were followed by a winter campaign in Picardy, where he succeeded in preventing the junction of the English and Imperialists, besides obtaining some advantages over the former, and harassing their retreat to the coast. He thus added to his popularity with the army, and acquired strong claims to the gratitude of the Parisians, deeply alarmed by the proximity of the enemy to the capital, and who viewed him as their saviour.
The year 1523 opened under menacing auspices. Germany, Italy, England, were leagued against France, whose sole allies were Scotland, the Swiss, (the adhesion of these depending entirely on regular subsidies,) and the Duke of Savoy, whose chief merit was that he could facilitate the passage of the Alps. Undeterred, almost foolhardy, Francis, instead of prudently standing on the defensive, beheld, in each new opponent, only a fresh source of glory. Unhappily for him, at the very moment he had greatest need of skilful captains, the Constable of Bourbon, irritated and persecuted in France, courted and seduced by the astute Charles V., entered into a treasonable combination with the Imperialists. It was discovered; he fled, and effected his escape. Out of France, he was but one man the less, but that man was such a leader as could hardly be replaced, and Charles gave him command of his troops in the Milanese. The Constable's misconduct brought disfavour on the princes of the house of Bourbon, (of that of Valois none remained,) and this further increased the credit and importance of the Count of Guise. He was already governor of Champagne and Burgundy, provinces the Emperor was likely to attack. This command, however, was not the object of his desires; he would rather have gone to Italy, and applied to do so; but the King, rendered suspicious by the Constable's defection, began to consider, with some slight uneasiness, the position acquired by the Count of Guise; and it was probably on this account only that he would not confer on the Lorraine prince the direction of the Italian war. The glory of Guise lost nothing by the refusal, although that of France grievously suffered by the army of Italy being confided to the less capable hands of Admiral Bonnivet. Fortune soon afforded the younger general one of those opportunities of high distinction, of which no leader ever was more covetous or better knew how to take advantage. A large body of Imperialist infantry having made an irruption into Burgundy, he assembled the nobility of the province and about nine hundred men-at-arms, with which force he deemed himself able to keep the field against the twelve thousand lansquenets that Count Furstemberg led to meet him. By an odd accident, he had no infantry, his adversary no cavalry. By dividing his horsemen into small parties, and maintaining an incessant harassing warfare, Guise prevented the Germans from foraging; and at last, compelled by famine, they prepared to recross the Meuse, abandoning two forts they had captured, and carrying off a large amount of spoil. Thus encumbered, and vigorously pursued, their rearguard was cut to pieces, and their retreat converted into a rout. "With a feeling of chivalrous gallantry," says M. de Bouillé, "Guise desired to procure the duchess his sister-in-law, Antoinette de Bourbon, and the ladies of the court of Lorraine, then assembled at Neufchâteau, the enjoyment of this spectacle, (the battle), to them so new. Warned by him, and stationed at windows, out of reach of danger, whence they looked out upon the plain, they had the pastime, and were able to recompense, by their applause and cries of joy, the courage of the troops whom their presence animated."
But such partial successes, however glorious to him by whom they were achieved, were all insufficient to turn the tide of disaster that had set in against the French arms. The defeat of Bonnivet, the invasion of Provence by the Constable, were succeeded by that terrible day before the walls of Pavia, when Francis I., vanquished, wounded, made prisoner by a rebellious subject, beheld his army destroyed, and the battle-field strewn with the bodies of his best generals, whilst, bleeding at his feet, slain in his defence, lay Francis of Lorraine, a younger brother of the Count of Guise, the second of that brave brotherhood who had fallen in arms under the fleur-de-lis.2 When the brave but most imprudent monarch was carried into captivity, his mother, regent in his absence, placed her chief trust and dependence in Guise. Of these he proved himself worthy. He checked the ambition of the Duke of Vendôme, who, as first prince of the blood, showed a disposition to seize upon the regency; he advised the ransoming of the French prisoners taken at Pavia, and exercised altogether a most salutary influence upon the circumstances of that critical time. His good sword, as well as his precocious wisdom, was soon in request. A large body of German fanatics, proclaiming the doctrine of absolute equality, and the abolition of all human superiority, had swept over Suabia, Wurtemberg, and Franconia, burning churches and slaying priests, and threatened to carry the like excesses into Lorraine and Burgundy.