97 O’Brien, K., Breyne, K., Ughetto, S., Laurent, L.C., and Breakefield, X.O. (2020). RNA delivery by extracellular vesicles in mammalian cells and its applications. Nat. Rev. Mol. Cell Biol. 21: 585–606.
98 Pascut, D., Cavalletto, L., Pratama, M.Y., Bresolin, S., Trentin, L., Basso, G., Bedogni, G., Tiribelli, C., and Chemello, L. (2019). Serum miRNA are promising biomarkers for the detection of early hepatocellular carcinoma after treatment with direct-acting antivirals. Cancers (Basel) 11.
99 Pavuk, M., Olson, J.R., Sjodin, A., Wolff, P., Turner, W.E., Shelton, C., Dutton, N.D., Bartell, S., and Anniston Environmental Health Research Consortium (2014). Serum concentrations of polychlorinated biphenyls (PCBs) in participants of the Anniston Community Health Survey. Sci. Total Environ. 0: 473–474: 286–297.
100 Petralia, F., Aushev, V.N., Gopalakrishnan, K., Kappil, M.N.W.K., Chen, J., Teitelbaum, S.L., and Wang, P. (2017). A new method to study the change of miRNA-mRNA interactions due to environmental exposures. Bioinformatics 33: i199–i207.
101 Qiao, J., Du, Y., Yu, J., and Guo, J. (2019). MicroRNAs as potential biomarkers of insecticide exposure: A review. Chem. Res. Toxicol. 32: 2169–2181.
102 Rager, J.E., Auerbach, S.S., Chappell, G.A., Martin, E., Thompson, C.M., and Fry, R.C. (2017). Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem. Res. Toxicol. 30: 1911–1920.
103 Rager, J.E., Bailey, K.A., Smeester, L., Miller, S.K., Parker, J.S., Laine, J.E., Drobna, Z., Currier, J., Douillet, C., Olshan, A.F., Rubio-Andrade, M., Styblo, M., Garcia-Vargas, G., and Fry, R.C. (2014). Prenatal arsenic exposure and the epigenome: Altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ. Mol. Mutagen 55: 196–208.
104 Ramaiahgari, S.C., Auerbach, S.S., Saddler, T.O., Rice, J.R., Dunlap, P.E., Sipes, N.S., Devito, M.J., Shah, R.R., Bushel, P.R., Merrick, B.A., Paules, R.S., and Ferguson, S.S. (2019). The power of resolution: contextualized understanding of biological responses to liver injury chemicals using high-throughput transcriptomics and benchmark concentration modeling. Toxicol. Sci. 169: 553–566.
105 Rider, C.F., Yamamoto, M., Gunther, O.P., Hirota, J.A., Singh, A., Tebbutt, S.J., and Carlsten, C. (2016). Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J. Allergy Clin. Immunol. 138: 1690–1700.
106 Robles-Diaz, M., Medina-Caliz, I., Stephens, C., Andrade, R.J., and Lucena, M.I. (2016). Biomarkers in DILI: One more step forward. Front Pharmacol. 7: 267.
107 Rodosthenous, R.S., Coull, B.A., Lu, Q., Vokonas, P.S., Schwartz, J.D., and Baccarelli, A.A. (2016). Ambient particulate matter and microRNAs in extracellular vesicles: A pilot study of older individuals. Part Fibre Toxicol. 13: 13.
108 Ruiz-Vera, T., Ochoa-Martinez, A.C., Zarazua, S., Carrizales-Yanez, L., and Perez-Maldonado, I.N. (2019). Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water. Environ. Toxicol. Pharmacol. 67: 79–86.
109 Saliminejad, K., Khorram Khorshid, H.R., and Ghaffari, S.H. (2019). Why have microRNA biomarkers not been translated from bench to clinic? Future Oncol. 15: 801–803.
110 Santangelo, L., Giurato, G., Cicchini, C., Montaldo, C., Mancone, C., Tarallo, R., Battistelli, C., Alonzi, T., Weisz, A., and Tripodi, M. (2016). The RNA-binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNA sorting. Cell Rep. 17: 799–808.
111 Schembri, F., Sridhar, S., Perdomo, C., Gustafson, A.M., Zhang, X., Ergun, A., Lu, J., Liu, G., Zhang, X., Bowers, J., Vaziri, C., Ott, K., Sensinger, K., Collins, J.J., Brody, J.S., Getts, R., Lenburg, M.E., and Spira, A. (2009). MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc. Natl. Acad. Sci. USA 106: 2319–2324.
112 Sharapova, T., Devanarayan, V., Leroy, B., Liguori, M.J., Blomme, E., Buck, W., and Maher, J. (2016). Evaluation of miR-122 as a serum biomarker for hepatotoxicity in investigative rat toxicology studies. Vet. Pathol. 53: 211–221.
113 Sharma, S. and Lu, H.C. (2018). microRNAs in Neurodegeneration: Current findings and potential impacts. J. Alzheimers Dis. Parkinsonism 8.
114 Shurtleff, M.J., Temoche-diaz, M.M., Karfilis, K.V., Ri, S., and Schekman, R. (2016). Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction. Elife 5.
115 Sima, M., Rossnerova, A., Simova, Z., and Rossner, P., JR. (2021). The impact of air pollution exposure on the microRNA machinery and lung cancer development. J. Pers. Med. 11 (1): 60. doi: 10.3390/jpm11010060.
116 Sisto, R., Capone, P., Cerini, L., Sanjust, F., Paci, E., Pigini, D., Gatto, M.P., Gherardi, M., Gordiani, A., L’Episcopo, N., Tranfo, G., and Chiarella, P. (2019). Circulating microRNAs as potential biomarkers of occupational exposure to low dose organic solvents. Toxicol. Rep. 6: 126–135.
117 Smith, A., Calley, J., Mathur, S., Qian, H.R., Wu, H., Farmen, M., Caiment, F., Bushel, P.R., Li, J., Fisher, C., Kirby, P., Koenig, E., Hall, D.G., and Watson, D.E. (2016). The rat microRNA body atlas: Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog. BMC Genom. 17: 694.
118 Sollome, J., Martin, E., Sethupathy, P., and Fry, R.C. (2016). Environmental contaminants and microRNA regulation: Transcription factors as regulators of toxicant-altered microRNA expression. Toxicol. Appl. Pharmacol. 312: 61–66.
119 Song, L., Zhang, Z., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., and Feng, F. (2016). Ratio of microRNA-122/155 in isoniazid-induced acute liver injury in mice. Exp. Ther. Med. 12: 889–894.
120 Song, M.K. and Ryu, J.C. (2015). Blood miRNAs as sensitive and specific biological indicators of environmental and occupational exposure to volatile organic compound (VOC). Int. J. Hyg. Environ. Health 218: 590–602.
121 Sork, H., Corso, G., Krjutskov, K., Johansson, H.J., Nordin, J.Z., Wiklander, O.P.B., Lee, Y.X.F., Westholm, J.O., Lehtio, J., Wood, M.J.A., Mager, I., and El Andaloussi, S. (2018). Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome. Sci. Rep. 8: 10813.
122 Srinivasan, S., Yeri, A., Cheah, P.S., Chung, A., Danielson, K., De Hoff, P., Filant, J., Laurent, C.D., Laurent, L.D., Magee, R., Moeller, C., Murthy, V.L., Nejad, P., Paul, A., Rigoutsos, I., Rodosthenous, R., Shah, R.V., Simonson, B., To, C., Wong, D., Yan, I.K., Zhang, X., Balaj, L., Breakefield, X.O., Daaboul, G., Gandhi, R., Lapidus, J., Londin, E., Patel, T., Raffai, R.L., Sood, A.K., Alexander, R.P., Das, S., and Laurent, L.C. (2019). Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation. Cell 177 (446–462): e16.
123 Starkey Lewis, P.J., Dear, J., Platt, V., Simpson, K.J., Craig, D.G., Antoine, D.J., French, N.S., Dhaun, N., Webb, D.J., Costello, E.M., Neoptolemos, J.P., Moggs, J., Goldring, C.E., and Park, B.K. (2011). Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology 54: 1767–1776.
124 Statello, L., Maugeri, M., Garre, E., Nawaz, M., Wahlgren, J., Papadimitriou, A., Lundqvist, C., Lindfors, L., Collen, A., Sunnerhagen, P., Ragusa, M., Purrello, M., Di Pietro, C., Tigue, N., and Valadi, H. (2018). Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes. PLoS One 13: e0195969.
125 Stermer, A.R., Reyes, G., Hall, S.J., and Boekelheide, K. (2019). Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol. Sci. 169: 399–408.
126 Straumfors, A., Duale, N., Foss, O.A.H., and Mollerup, S. (2020). Circulating miRNAs as molecular markers