Data Analytics in Bioinformatics. Группа авторов. Читать онлайн. Newlib. NEWLIB.NET

Автор: Группа авторов
Издательство: John Wiley & Sons Limited
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Жанр произведения: Программы
Год издания: 0
isbn: 9781119785606
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      Building Computational model includes study of different behavior of complex system to get some new insights for deepening our understanding. In this section we will discuss some prerequisites which are required for building the computational model.

       3.3.1 Data Pre-Processing and its Necessity

      We will address some of the problems which need to be solved to achieve better classification result. It involves cleaning of noisy data, missing data, duplicate data, etc. from the database to smoothly conduct the classification process. Noisy data refers to the unnecessary information available in the dataset which is meaningless and cannot be interpreted by machines. It can also be called corrupt data. Presence of these data can affect the data preparation process. To smooth the noisy data binning, clustering, regression methods can be used or can simply be deleted from large datasets based on the amount of noise present [11, 12]. Another biggest problem in biological data is the absence of values. In complex biological datasets this issue greatly impacts the performance of accuracy of the model. So to handle missing values various imputation techniques have to be used [12]. Data duplication are ongoing data quality problem testified in diverse domains, including health care, business and molecular biology, etc. [13] Presences of duplicate data leads to data inconsistency and redundancy which produces several consequences in classification problem. This issue can be handled by detecting and eliminating duplicate values.

      Biological data may contain thousands of features because they are highly dependent on comparing the behavior of various biological units. These data often contains large amount of irrelevant data which affect the classification accuracy and machine learning efficiency [14]. Dimensionality reduction technique focuses on reducing the number of input features which aids to reduce computation time and redundant data. Dimensionality can be reduced using different method such as Linear Discriminant Analysis (LDA), Principal Component Analysis (PCA), feature selection, etc.

       3.3.2 Biological Data Classification

      Databases are the rich source of hidden information which can be extracted for intelligent decision making. Classification is a process by which data is organized into different categories by determining a class for an element in database. Data is grouped into different classes based on the training dataset. The classification process helps analyze data and to build models that define data classes and predict future trends.

      The availability of large amount of microarray data has created new scopes in classification methods. Like classification of DNA microarrays contributes significantly for diagnosis and prognosis in many clinical practices [15].

       3.3.3 ML in Bioinformatics

      Machine learning (ML) is a technique to develop computer program to access data and to learn knowledge automatically from experience without human interventions and assistance. Machine learning techniques and deep learning algorithms enable the classifier to make use of automatic feature learning technique, to make reasonably complex predictions when the model is being trained on large datasets. It means the algorithm is able to learn based on the dataset alone and can discover ways to integrate numerous features of the input information into one intellectual set of features from which further learning can be done [9]. Machine learning technique uses two different methods to train the model: supervised learning and unsupervised learning method [16]. In subsequent sections we will discuss machine learning models used for supervised learning problems.

      In recent years, availability of biological datasets have risen abruptly, this has enabled bioinformatics researchers to make use of these machine learning algorithms. ML techniques has been applied to many biological domains such as Microarrays, Systems biology, Genomics, Proteomics, Stroke diagnosis and Text mining, etc. [8].

       Machine learning in bioinformatics helps to explore, analyze, manage and store data to extract relevant information from biological data.

       Gene identification and nucleotide identification help to understand gene and gene association with disease.

       Machine learning tools are also used to determine genomic sequence and examine gene pattern.

       Gene sequence classification allows us to grasp the concept of nucleic acid and protein sequence.

      There are many machine learning techniques among which Artificial Neural Network is an effective technique for the identification, selection, classification and prediction of the gene in the DNA Sequences.

       3.3.4 Introduction to ANN

      ANN is a computing system that resembles human brain, consisting of highly interconnected network of processing units called neurons. It has the ability to handle complex features within data in order to process the information.

      Figure 3.2 represents the simple work flow of artificial neural network with a perceptron architecture, which consists of one input layer with few input units representing multiple features present in the database, depending on the objective being defined. Each inputs collected from the dataset are multiplied with weights and fed to a function called activation function to produce the actual output.

      Depending on the difference between desired output and actual output weights are modified in each layer of connection and finally output is predicted. Weights are machine learnt values from neural networks. Neural network learns by a feedback process called backpropagation. In backpropagation, weights are modified from the output layer to the input layer, going backward through hidden layer to lessen the difference between actual output and desired output to a certain point [18]. Therefore, backpropagation algorithm helps to reduce the overall computational loss of the network while learning the network. The number of hidden layers used for computation and the type of computation being done in each layer together determine the processing speed of the network.

Schematic illustration of the simple network architecture of ANN with four input unit.

      Figure 3.2 Simple network architecture of ANN with four input unit [17].