Hepatic hematomas may be variable in appearance and initially are generally anechoic or hypoechoic to normal hepatic parenchyma. Hematomas may be difficult to distinguish from other mass lesions, including neoplasia (hemangiosarcoma). Frequently, large hematomas usually form with ruptured hepatic masses and can complicate diagnosis (Figure 8.8A,B; see also Figure 8.7B). Fine needle aspiration of hematomas generally yields nonspecific cytological results and the absence of neoplastic cells on cytology does not rule out neoplasia.Figure 8.6. Hepatic cyst and biliary cysts. (A) Hepatic cyst (arrow) with distal acoustic enhancement (seen as a hyperechoic, bright enhancement extending from the far margin of the hepatic cyst and marked with subtle black cursors [> <] on both sides of the hyperechoic track). Hepatic cysts are typically thin‐walled and filled with anechoic fluid. A fluid‐filled structure can be differentiated from a solid nodule by looking in the far‐field for acoustic enhancement artifact (the bright track extending from the far field of the cyst to the text L LIVER). A solid or mineralized structure will conversely have acoustic shadowing artifact in the far‐field (a dark track extending from the far‐field of the solid or mineralized structure). (B) Multiple benign biliary cystadenomas in a cat (labeled liver masses by the sonographer). This can be mistaken for malignant cystic neoplasia. (C) Large hepatic cyst in a dog. Note the large anechoic structure with distal acoustic enhancement artifact extending from the far border of the cyst (labeled > <). Cysts can be complex in architecture and within this cyst is a large, echogenic, ovoid to amorphous structure. Irregularly marginated cysts or those containing echogenic material can be malignant. An additional differential for the structure within the cyst includes fibrinous material or hemorrhage and may represent abscessation, inflammation or neoplastic change. Fine needle aspiration may allude to the diagnosis. Alternatively, excisional biopsy may be needed.
Neoplastic lesions have a wide range of morphological changes. Again, it should be emphasized that it is not possible to distinguish between benign and malignant lesions based on ultrasonographic appearance alone. There are a variety of primary liver tumors including hepatocellular adenoma and adenocarcinoma as well as mesenchymal tumors (see Figure 8.7B–D). Lymphosarcoma can appear as either focal or multifocal mass lesions or as diffuse parenchymal disease. Hemangiosarcoma generally appears as complex mass lesions with mixed echogenicity and cavitations (see Figures 8.7B and 8.8A,B). Hematomas can have a similar appearance. Metastatic neoplasia is common in the liver (Figure 8.9A,B). Hepatic mass lesions must be characterized by cytology or histopathology for a definitive diagnosis. Ultrasound‐guided fine needle or Tru‐Cut biopsy of mass lesions can usually be accomplished with minimal difficulty and risk, depending on the location of the mass.Figure 8.7. Various liver masses. Benign and malignant liver masses cannot be differentiated based on ultrasound characteristic alone. (A) Semisolid hepatic mass in a cat confirmed to be a hepatic abscess. The gallbladder (GB) is juxtaposed to the mass and may be confused with free fluid on this still image, highlighting the value of a several‐second video when images are submitted to the specialist for interpretation. Although not always present, the hallmark of an abscess regardless of location is the presence of gas within the mass effect as evidenced by comet tails and other air‐related artifacts caused by gas‐producing bacteria (such artifacts are not evident here). Diagnosis was made by liver biopsy. (B) A large, mixed echogenicity mass (MASS). It can be difficult to determine the origin of large masses. The liver, spleen, kidney or other adjacent structures should be considered if a region of organ confluence cannot be identified. The histopathological diagnosis in this case was hepatic hemangiosarcoma. (C) Another example of mixed echogenicity with a hepatic mass adjacent to the diaphragm. Note the abrupt change of echogenicity between the mass and normal hepatic parenchyma. Percutaneous biopsy result was hepatocellular carcinoma. (D) Large hyperechoic, lobulated mass with mild peritoneal effusion within the gallbladder fossa. The lesion was confirmed to be hepatocellular carcinoma. Note the differences between sonographic appearances of the same tumor type in (C) and (D) demonstrating the poor specificity of ultrasonographic findings with regard to histopathological diagnosis. Additional differentials might have included a hepatoma (benign liver mass) or other types of solid parenchymal neoplasia (GB, gallbladder; RLiver, right liver; RK, right kidney).Figure 8.8. Liver and splenic masses. The origin of large masses can be challenging to determine ultrasonographically and is sometimes not possible. (A) and (B) show the same large mass in a dog with mixed echogenicity (unlabeled and labeled). Careful evaluation showed confluence of the tumor with the splenic parenchyma. (C,D) Images of a cat (same patient) with hepatic mast cell tumor. Note that a well‐defined mass is not seen. Rather, the parenchymal changes are subtle and the liver is coarse in echotexture. This case highlights the importance of fine needle aspirate and/or liver biopsy in obtaining the patient’s definitive diagnosis.
Target lesions consist of alternating layers of different echogenicities, giving the appearance of a target or bull's eye. Single target lesions have a high predictive value for malignancy. Multiple target lesions increase the positive predictive value of malignancy up to 74–81% (Cuccovillo and Lamb 2002) (see Figure 8.9A,B). Regardless, target lesions are nonspecific and a biopsy is required for further characterization. If target lesions are detected, then the authors recommend screening for additional evidence of neoplasia with a complete detailed abdominal ultrasound, thoracic radiographs, and lung ultrasound. However, performing a Global FAST immediately following your POCUS examination is helpful for a quick survey of the remaining abdominal structures, the thorax (TFAST), and lung surface, especially for nodules (Vet BLUE).
Liver Parenchymal Disease
Ultrasonography is not always sensitive for evaluating diffuse parenchymal disease, and diffuse disease may be more challenging to assess than focal disease because sonographic changes are more easily overlooked or may not be present. When there is a high index of suspicion for diffuse hepatic disease, fine needle aspiration or biopsy is indicated to confirm a diagnosis, and ultrasound guidance can assist with these procedures. Despite sonographic limitations, some generalizations can be made regarding changes in echogenicity.
Figure 8.9. Liver masses. (A) Image of a dog with target lesions of the hepatic parenchyma. These lesions are generally considered malignant and may be