Human Metabolism
A Regulatory Perspective
Fourth Edition
Keith N. Frayn
Emeritus Professor of Human Metabolism
Radcliffe Department of Medicine
University of Oxford
Oxford, UK
and
Rhys D. Evans
Reader in Metabolic Biochemistry
Department of Physiology, Anatomy and Genetics
University of Oxford
Oxford, UK
and
Consultant in Anaesthetics and Intensive Care Medicine
Oxford University Hospitals NHS Trust
John Radcliffe Hospital
Oxford, UK
This edition first published 2019 © 2019 Keith N. Frayn and Rhys D. Evans
Edition History Portland Press (1e, 1996); Blackwell Science (2e, 2003); Wiley-Blackwell (3e, 2010). (Editions 1 to 3 published under the title of Metabolic Regulation: A Human Perspective.)
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Library of Congress Cataloging-in-Publication Data Names: Frayn, K. N. (Keith N.), author. | Evans, Rhys D. (Rhys David), author. Title: Human metabolism : a regulatory perspective / Keith N. Frayn and Rhys D. Evans. Other titles: Metabolic regulation Description: Fourth edition. | Hoboken, NJ : Wiley-Blackwell, 2019. | Preceded by Metabolic regulation / Keith N. Frayn. 3rd ed. 2010. | Includes bibliographical references and index. | Identifiers: LCCN 2018039797 (print) | LCCN 2018041323 (ebook) | ISBN 9781119331445 (Adobe PDF) | ISBN 9781119331469 (ePub) | ISBN 9781119331438 (paperback) Subjects: | MESH: Metabolism—physiology | Metabolic Diseases—physiopathology | Metabolic Networks and Pathways—physiology Classification: LCC QP171 (ebook) | LCC QP171 (print) | NLM QU 120 | DDC 612.3/9—dc23 LC record available at https://lccn.loc.gov/2018039797
Cover images: courtesy of Keith Frayn and Rhys Evans, © John Wiley & Sons, Inc.
Cover design by Wiley
CONTENTS
1 Cover
2 Preface
5 CHAPTER 1 The underlying principles of human metabolism 1.1 Metabolism in perspective 1.2 The chemistry of food – and of bodies 1.3 General overview of metabolism Note
6 CHAPTER 2 Cellular aspects of metabolic regulation 2.1 What is metabolic regulation? 2.2 What makes one tissue different from another? 2.3 Rapid changes in metabolic flux and how they are achieved 2.4 Longer-term control of metabolic pathways Note
7 CHAPTER 3 Coordination of metabolism in the whole body 3.1 Metabolic regulation involves communication between tissues 3.2 What connects the tissues?