17 9 Toxicity Protocols for Natural Products in the Drug Development Process 9.1 Introduction 9.2 In Vitro Toxicity Testing for Natural Products 9.3 Methods Used for In Vitro Toxicity Studies 9.4 In Vitro Models for Liver Toxicity 9.5 In Vitro Models for Nephrotoxicity Studies 9.6 In Vitro Model for Dermal Toxicity Testing 9.7 Mutagenicity Testing In Vitro 9.8 Reproductive and Teratogenicity Studies In Vitro 9.9 In Vivo Toxicity Testing of Natural Products 9.10 Conclusion References
18 10 Quality Control for the Safety of Natural Products 10.1 Introduction 10.2 Quality Assurance of Herbal Products 10.3 Methods of Quality Control for Herbal Products 10.4 WHO Guidelines for Quality Standardization of Herbal Formulations 10.5 Concept of Validation in Herbal Products 10.6 Challenges Related to Quality Control and Monitoring the Safety of Herbal Products References
19 11 Secondary Metabolites and Toxins of Microbial Origin for the Treatment of Diseases 11.1 Introduction 11.2 Antimicrobial Agents from Microbial Sources 11.3 Antifungal Agents from Microbial Sources 11.4 Anticancer Agents from Microbial Sources 11.5 Hypocholesterolemic Agents from Microbial Sources 11.6 Immunosuppressants from Microbial Sources 11.7 Enzyme Inhibitors from Microbial Sources 11.8 Antiparasitic Agents from Microbial Sources 11.9 Recent Advances in Drug Discovery from Microbial Sources References
20 12 Development of Phyto‐Antidotes Against Adverse Chemical Agents 12.1 Introduction 12.2 Heavy Metals and their Effects on the Body 12.3 Detoxification Properties of Biologically Active Substances of Plant‐Based Foods 12.4 Current State of Clinical Application of Phyto‐Antidotes 12.5 Further Prospects in the Search for Promising Phyto‐Antidotes 12.6 Conclusions References
21 13 Nanoformulated Herbal Drug Delivery as Efficient Antidotes Against Systemic Poisons 13.1 Introduction 13.2 Herbal Phytochemicals as Antidotes for Systemic Poisons 13.3 Nanoformulated Herbal Phytochemicals as Antidotes 13.4 Mechanism of Nanoformulated Herbal Phytochemicals against Systemic Poisoning 13.5 Future Perspectives 13.6 Conclusion References
22 14 Phytochemical‐Based Nanoparticles as Foes and Friends 14.1 Introduction 14.2 Phytochemicals Used in the Synthesis of Nanoparticles 14.3 Anti‐Inflammatory Effects of Nanoparticles 14.4 Wound‐Healing Effects of Nanoparticles 14.5 Antiparasitic, Antifungal, and Antibacterial Activities of Nanoparticles 14.6 Neuroprotective Effects of Nanoparticles 14.7 Cardioprotective Effects of Nanoparticles 14.8 Anticancer Effects of Nanoparticles 14.9 Advantages of Nanoparticles 14.10 Disadvantages of Nanoparticles 14.11 Conclusion and Future Directions References
23 15 Application of Metabolomics in Emergency Phytochemical Poisoning and Remediation 15.1 Introduction