455
Fair WR, Clark RB, Wehner N. A correlation of seminal polyamine levels and semen analysis in the human. Fertil Steril. 1972;23(1):38–42. https://pubmed.ncbi.nlm.nih.gov/5008948/
456
Definition of testament. Merriam-Webster.com. https://www.merriam-webster.com/dictionary/testament. Accessed February 11, 2023.; https://www.merriam-webster.com/dictionary/testament
457
Agricultural Research Service, United States Department of Agriculture. Wheat germ, plain. FoodData Central. https://fdc.nal.usda.gov/fdc-app.html?query=wheat+germ&utf8=%E2%9C%93&affiliate=usda&commit=Search#/food-details/1101819/nutrients. Published October 30, 2020. Accessed April 30, 2021.; https://fdc.nal.usda.gov/fdc-app.html?query=wheat+germ&utf8=%E2%9C%93&affiliate=usda&commit=Search#/food-details/1101819/nutrients
458
Liaqat H, Jeong E, Kim KJ, Kim JY. Effect of wheat germ on metabolic markers: a systematic review and meta-analysis of randomized controlled trials. Food Sci Biotechnol. 2020;29(6):739–49. https://pubmed.ncbi.nlm.nih.gov/32523783/
459
McCarty MF, Lerner A. Perspective: low risk of Parkinson’s disease in quasi-vegan cultures may reflect GCN2-mediated upregulation of Parkin. Adv Nutr. 2021;12(2):355–62. https://pubmed.ncbi.nlm.nih.gov/32945884/
460
Cara L, Borel P, Armand M, et al. Plasma lipid lowering effects of wheat germ in hypercholesterolemic subjects. Plant Foods Hum Nutr. 1991;41(2):135–50. https://pubmed.ncbi.nlm.nih.gov/1649472/
461
Moreira-Rosário A, Pinheiro H, Marques C, Teixeira JA, Calhau C, Azevedo LF. Does intake of bread supplemented with wheat germ have a preventive role on cardiovascular disease risk markers in healthy volunteers? A randomised, controlled, crossover trial. BMJ Open. 2019;9(1):e023662. https://pubmed.ncbi.nlm.nih.gov/30659039/
462
Atallahi M, Amir Ali Akbari S, Mojab F, Alavi Majd H. Effects of wheat germ extract on the severity and systemic symptoms of primary dysmenorrhea: a randomized controlled clinical trial. Iran Red Crescent Med J. 2014;16(8). https://pubmed.ncbi.nlm.nih.gov/25389490/
463
Delzenne NM, Neyrinck AM, Cani PD. Gut microbiota and metabolic disorders: how prebiotic can work? Br J Nutr. 2013;109 Suppl 2:S81–5. https://pubmed.ncbi.nlm.nih.gov/23360884/
464
Milovic V. Polyamines in the gut lumen: bioavailability and biodistribution. Eur J Gastroenterol Hepatol. 2001;13(9):1021–5. https://pubmed.ncbi.nlm.nih.gov/11564949/
465
Matsumoto M, Kurihara S, Kibe R, Ashida H, Benno Y. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS One. 2011;6(8):e23652. https://pubmed.ncbi.nlm.nih.gov/21858192/
466
Noack J, Kleessen B, Proll J, Dongowski G, Blaut M. Dietary guar gum and pectin stimulate intestinal microbial polyamine synthesis in rats. J Nutr. 1998;128(8):1385–91. https://pubmed.ncbi.nlm.nih.gov/9687560/
467
Hunter DC, Burritt DJ. Polyamines of plant origin: an important dietary consideration for human health. In: Rao V, ed. Phytochemicals as Nutraceuticals: Global Approaches to Their Role in Nutrition and Health. InTech; 2012:225–44. https://www.intechopen.com/chapters/32904
468
Mäkivuokko H, Tiihonen K, Tynkkynen S, Paulin L, Rautonen N. The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition. Br J Nutr. 2010;103(2):227–34. https://pubmed.ncbi.nlm.nih.gov/19703328/
469
Hunter DC, Burritt DJ. Polyamines of plant origin: an important dietary consideration for human health. In: Rao V, ed. Phytochemicals as Nutraceuticals: Global Approaches to Their Role in Nutrition and Health. InTech; 2012:225–44. https://www.intechopen.com/chapters/32904
470
Matsumoto M, Aranami A, Ishige A, Watanabe K, Benno Y. LKM512 yogurt consumption improves the intestinal environment and induces the T-helper type 1 cytokine in adult patients with intractable atopic dermatitis. Clin Exp Allergy. 2007;37(3):358–70. https://pubmed.ncbi.nlm.nih.gov/17359386/
471
Matsumoto M, Kurihara S, Kibe R, Ashida H, Benno Y. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production. PLoS One. 2011;6(8):e23652. https://pubmed.ncbi.nlm.nih.gov/21858192/
472
Kibe R, Kurihara S, Sakai Y, et al. Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Sci Rep. 2014;4(1):4548. https://pubmed.ncbi.nlm.nih.gov/24686447/
473
Matsumoto M, Kitada Y, Naito Y. Endothelial function is improved by inducing microbial polyamine production in the gut: a randomized placebo-controlled trial. Nutrients. 2019;11(5). https://pubmed.ncbi.nlm.nih.gov/31137855/
474
Matsumoto M. Prevention of atherosclerosis by the induction of microbial polyamine production in the intestinal lumen. Biol Pharm Bull. 2020;43(2):221–9. https://pubmed.ncbi.nlm.nih.gov/32009110/
475
Noack J, Kleessen B, Proll J, Dongowski G, Blaut M. Dietary guar gum and pectin stimulate intestinal microbial polyamine synthesis in rats. J Nutr. 1998;128(8):1385–91. https://pubmed.ncbi.nlm.nih.gov/9687560/
476
de Cabo R, Navas P. Spermidine to the rescue for an aging heart. Nat Med. 2016;22(12):1389–90. https://pubmed.ncbi.nlm.nih.gov/27923032/
477
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359(6374):eaan2788. https://pubmed.ncbi.nlm.nih.gov/29371440/
478
Pietrocola F, Castoldi F, Kepp O, Carmona-Gutierrez D, Madeo F, Kroemer G. Spermidine reduces cancer-related mortality in humans. Autophagy. 2019;15(2):362–5. https://pubmed.ncbi.nlm.nih.gov/30354939/
479
Chavez-Dominguez R, Perez-Medina M, Lopez-Gonzalez JS, Galicia-Velasco M, Aguilar-Cazares D. The double-edge sword of autophagy in cancer: from tumor suppression to pro-tumor activity. Front Oncol. 2020;10. https://pubmed.ncbi.nlm.nih.gov/33117715/
480
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359(6374):eaan2788. https://pubmed.ncbi.nlm.nih.gov/29371440/
481
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018;359(6374):eaan2788. https://pubmed.ncbi.nlm.nih.gov/29371440/
482
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