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I would like to dedicate this edition to two true experts in vulval disease whom I have been privileged to work with and who continue to teach me
Sallie Neill, my mentor in this subject and good friend, for continuous support and encouragement in clinical scenarios, teaching and publication.
Micheline Moyal‐Barracco, my friend, teaching colleague, and collaborator, who always challenges me to think, learn, and develop new concepts.
List of Contributors
Alia Ahmed Consultant Dermatologist Frimley Health NHS Trust UK
Fabrizio Bogliatto Department of Obstetrics and Gynaecology Ivrea Hospital Italy
Nina Bohm‐Starke Department of Obstetrics and Gynaecology Danderyd Hospital Stockholm Sweden
Eduardo Calonje Director of Dermatopathology St John's Institute of Dermatology Guy's & St Thomas' Hospital London UK
Kristiana Gordon Department of Dermatology St George’s Hospital London UK
Ulrika Johannesson Department of Obstetrics and Gynaecology Danderyd Hospital Stockholm Sweden
Refaat Karim Plastic Surgeon Medical Director Aklinieken The Netherlands
Fiona M. Lewis Consultant Dermatologist St John’s Institute of Dermatology Guy's & St. Thomas' NHS Foundation Trust Guy's Hospital London UK
Zlatko Marusic Clinical Department of Pathology and Cytology University Hospital Centre Zagreb Zagreb Croatia
Elisabet Nylander Department of Public Health and Clinical Medicine Dermatology and Venereology Umeå University Sweden
Ellie Rashidghamat St John’s Institute of Dermatology Guy’s & St Thomas’ NHS Foundation Trust London UK
Gulshan Sethi Consultant Genito‐urinary Physician Guy’s & St Thomas’ NHS Foundation Trust London UK
Marc van Beurden Department of Gynaecological Oncology National Cancer Institute Amsterdam The Netherlands
Michelle van der Linden Department of Obstetrics and Gynaecology Radboud University Medical Center Nijmegen The Netherlands
Shireen Velangi Department of Dermatology University Hospitals Birmingham NHS Trust Birmingham UK
Preface
It is now over 10 years since the 3rd edition of Ridley’s The Vulva was published. Since that time, my co‐editor for that book, Dr Sallie Neill, has retired but has trusted me to continue with this new edition. It aims to provide a comprehensive update but also to include more topics now encompassed by the field of vulval disease.
Significant changes have been made to this 4th edition, with a more contemporary feel and a format that is easier to navigate. The number of chapters has therefore been increased to include new and emerging subjects. There are several new authors, all experts in their fields, who help to discuss old subjects in new ways. With the addition of an online edition, it is possible to provide additional references, clinical and histological images, and other resources.
Despite all these changes, the aim of the book has not changed from Marjorie Ridley’s original vision, and it will keep her name to acknowledge her pioneering work in this field. I hope it will therefore be a useful resource for all those involved in the management of patients with vulval disease and hence ultimately improve care for this patient group.
Fiona M. Lewis
Acknowledgements
I would like to thank all the contributors for their hard work in revising the old and writing the new chapters. I am especially grateful to my dermatopathology colleague, Dr Eduardo Calonje, not only for providing histology slides but also for his superb dedication to clinicopathological correlation and for teaching me so much in our weekly meetings to review vulval pathology. Dr Ágnes Pekár‐Lukacs has scanned most of the new histology slides to provide excellent‐quality images, and her contribution to this book has been enormous.
The staff at Wiley have provided great support, especially Rajalaxmi Rajendra Singh, who took on the administration of this edition with great skill. Jennifer Seward, the Managing Editor at Wiley, has been a constant help and guide and has tolerated my many queries with great patience. For this, I thank her.
Lastly, enormous thanks to my brother, Jeff Lewis, for ongoing help with grammar and spelling, and for being a good opinion in my attempts to make things understandable!
About the Companion Website
This book is accompanied by a companion website.
www.wiley.com/go/thevulva4e
This website includes:
Downloadable PDFs of the complete reference lists from the book.
Downloadable PowerPoint slides of over 100 extra figures.
1 Vulval Embryology and Developmental Abnormalities
Fiona M. Lewis
CHAPTER MENU
Vulval embryology Sexual determination and differentiation Early female embryogenesis (weeks 1–8) Carnegie stage 1–3 Carnegie stages 4–6 Carnegie stage 8 Carnegie stage 9 Carnegie stage 11 Carnegie stages 13 and 14 Carnegie stages 15 and 16 Carnegie stage 19 Carnegie stages 20–23 End of the female embryonic period and further development (week 8 onwards) Development of the epithelia
Disorders of Sexual Development Sex Chromosome DSD Turner’s syndrome Mosaicism