280
0.70
100
0.86
216 μg min/ml
Tenofovir disoproxil fumarate
503–606 ml/h/kg
161–194 ml/h/kg
0.32
300
0.25
136 μg h/ml/kg
Entecavir
588.1
360–471
0.62–0.73
1
1.0
1.7 μg min/ml
Asthma
Ipratropium
2,325
65.1
0.028
0.25
0.07
7.5 ng min/ml
Zafirlukast
19.4 l/h
1.9 l/h
0.10
20
NR
1.0 mg h/l
Cancer
Cisplatin
250–350 ml/min/m
2
50–62 ml/min/m
2
0.13–0.17
50 mg/m
2
1.0
166 μg min/ml
Topotecan
36–132 l/h/m
2
10.0–37.0 l/h/m
2
0.03–0.51
1.5 mg/m
2
1.0
17.9 μg h/l
Oxaliplatin
18.5–31.5 l/h
10–17 l/h
0.54
85 mg/m
2
1.0
3.5 mg h/l
Imatinib
8–14 l/h
0.72–1.26 l/h
0.05–0.13
400
0.98
36 mg h/l
Mesna/dimesna
1.23 l/h/kg
0.41 l/h/kg
0.33
5,000
0.89
3,618 mg h/l/kg
Cardiovascular
Procainamide
705
391
0.3–0.6
500
1.0
709 μg min/ml
Amiodarone
87.5
0
<1%
400
0.5
2.3 mg min/ml
Quinidine
2.8
0.7
0.05–0.20
200
0.7
50 mg min/ml
Depression
Imipramine
1 l/h/kg
0.001 l/h/kg
0.001
100 mg
0.95
95 mg h/l/kg
Diabetes
Metformin
542–642
542–642
1
850
0.55
779 μg min/ml
Hypertension
Captopril
0.8 l/h/kg
0.4 l/kg/h
0.95
25
0.75
23.4 mg h/l/kg
Diltiazem
11.8 ml/min/kg
4.13 ml/min/kg
0.35
120
0.95
9.7 mg min/ml/kg
Verapamil
10.4–12.4 ml/h/kg
7.3–8.7 ml/h/kg
0.70
120
0.20–0.35
2.9 mg h/l/kg
Clonidine
180–390
133
0.40–0.60
0.1
0.90
0.3 μg min/ml
Atenolol
100–176
95–168
0.40–0.50
50
0.50
17.8 μg min/ml
Nadolol
2.78–3.22 ml/min/kg
0.9–1.92 ml/min/kg
0.25
40
0.30
4.0 mg min/ml/kg
Leg cramps
Quinine
0.17 l/h/kg
0.034 l/h/kg
0.20
650
0.76–0.88
3,058 mg h/l/kg
Reflux disease
Cimetidine
30–48 l/h
13.8–30 l/h
0.48
400
0.73
7.3 mg h/l
a Units reported other than ml/min are delineated.
b Units reported other than mg are delineated.
TABLE 3.4 MATE1 and MATE2‐K inhibitors
