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      The right of Ramon Rios Torres to be identified as the author of the editorial material in this work has been asserted in accordance with law.

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       Library of Congress Cataloging-in-Publication Data

      Names: Riós Torres, Ramón, author.

      Title: Spiro compounds : synthesis and applications / Ramon Rios Torres, University of Southampton, Southhampton, United Kingdom.

      Description: First edition. | Hoboken, NJ : Wiley, 2022. | Includes index.

      Identifiers: LCCN 2021031988 (print) | LCCN 2021031989 (ebook) | ISBN 9781119567639 (hardback) | ISBN 9781119567622 (adobe pdf) | ISBN 9781119567653 (epub)

      Subjects: LCSH: Organic compounds–Structure.

      Classification: LCC QD255.4 .R56 2022 (print) | LCC QD255.4 (ebook) | DDC 547/.5–dc23

      LC record available at https://lccn.loc.gov/2021031988 LC ebook record available at https://lccn.loc.gov/2021031989

      Cover Design: Wiley

      Cover Image: © Connect world/Shutterstock

      List of Contributors

      Vikas R. Aswar Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

       Lu Bai Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, China

      Matthias Baud School of Chemistry and Institute for Life Sciences, University of Southampton, Southampton, UK

      Hak‐Fun Chow Department of Chemistry, Institute of Molecular Functional Materials and The Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, Hong Kong

      Xavier Companyó Department of Chemical Sciences, University of Padova, Padova, PD, Italy

      Xiao‐Yuan Cui School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

      Luca Dell’Amico Department of Chemical Sciences, University of Padova, Padova, PD, Italy

      Sambasivarao Kotha Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

      Dietmar Kuck Department of Chemistry and Center for Molecular Materials (CM2), Bielefeld University, Bielefeld, Germany

      Xinjun Luan Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an, China

      Marta Meazza School of Chemistry, University of Southampton, Southampton, UK

      Albert Moyano Secció de Química Orgànica, Departament de Química Inorgànica i Orgànica, Facultat de Química, Universitat de Barcelona, Barcelona, Catalonia, Spain

      Suva Paria Department of Chemical Sciences, University of Padova, Padova, PD, Italy

      Ramon Rios Department of Organic Chemistry, University of Southampton, Southampton, UK

      Yellaiah Tangella Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India

      Alberto Vega‐Peñaloza Department of Chemical Sciences, University of Padova, Padova, PD, Italy

      Jan Veselý Department of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

      Michal Urban Department of Organic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

      Peng‐Wei Xu School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

      Jin‐Sheng Yu School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

      Jian Zhou School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China

      Preface

      When I was a kid, I dreamt to be an engineer and build planes, cars, etc. However, in high school, I felt in love with Organic Chemistry. I changed my dreams of building things for how to assemble C, H, N, and other atoms to form molecules. I was always astonished of the inherent difficulty of organic structures, not only for their diversity and ordered assembly but also for their 3D shape. With time, I enjoyed learning Organic Chemistry: starting from my bachelor in organic chemistry, followed by a PhD in organometallic chemistry, and several postdocs in organometallic chemistry and organocatalysis. Later on, as academic, I have always tried to develop new reactions that can allow to obtain difficult structures in an enantiopure form. However, one of the greatest challenges that I faced has been the synthesis of spiro compounds.