CELL BIOLOGY
A Short Course
FOURTH EDITION
Stephen Bolsover
Andrea Townsend‐Nicholson
Greg FitzHarris
Elizabeth Shephard
Jeremy Hyams
Sandip Patel
This fourth edition first published 2022
© 2022 John Wiley & Sons Ltd
Edition History John Wiley & Sons, Inc. (From Genes to Cells, 1e, 1997) (2e, 2004) (3e, 2011)
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.
The right of Stephen Bolsover, Andrea Townsend‐Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, and Sandip Patel to be identified as the authors of this work has been asserted in accordance with law.
Registered Offices John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK
For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.
Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.
Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.
Library of Congress Cataloging‐in‐Publication Data applied for
Names: Bolsover, Stephen, 1954‐ author.
Title: Cell biology: a short course / Stephen Bolsover, Andrea Townsend‐Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel.
Description: Fourth edition. | Hoboken, NJ: Wiley‐Blackwell, 2022. | Includes bibliographical references and index.
Identifiers: LCCN 2021049318 (print) | LCCN 2021049319 (ebook) | ISBN 9781119757764 (hardback) | ISBN 9781119757771 (adobe pdf) | ISBN 9781119757788 (epub)
Subjects: LCSH: Cytology.
Classification: LCC QH581.2 .B65 2022 (print) | LCC QH581.2 (ebook) | DDC 571.6–dc23/eng/20211007
LC record available at https://lccn.loc.gov/2021049318 LC ebook record available at https://lccn.loc.gov/2021049319
Cover Design: Wiley
Cover Image: © Hybrid Medical Animation/Science Source
PREFACE
Our aim in previous editions of Cell Biology, A Short Course was to cover a wide area of cell biology in a form especially suitable for first‐year undergraduates, keeping the book to a manageable size so that neither the content, the cost, nor the weight was too daunting for the student. For the fourth edition we have thoroughly revised the content to concentrate on the core of cell biology: the structure of the cell, how it is made, and how cells and the parts of cells interact and move.
We begin (Section 1, Chapters 1 and 2) by describing the components of the cell as seen in the microscope. We then (Section 2, Chapters 3–8) turn to the central dogma of molecular biology and describe how DNA is used to make RNA which in turn is used to make protein. We end this section with chapters on protein structure and on recombinant DNA technology and genetic engineering. Section 3 (Chapters 9–11) describes how cells use electricity, ion concentrations, and chemical messengers to interact with and respond to external cues. Section 4 (Chapters 12–14) describes the physically moving cell: intracellular trafficking, the cytoskeleton and molecular motors, and cell division and death. Finally, in Section 5 (Chapter 15) we use cystic fibrosis as a case study that illustrates how all the areas of knowledge covered in this book contribute to an understanding of this disease and have allowed the development of novel clinical treatments.
Boxed