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Index

      32  End User License Agreement

      List of Tables

      1 Chapter 1Table 1.1 Pharmacokinetics and pharmacodynamics.Table 1.2 Medicine administration, preservation of safety.

      2 Chapter 2Table 2.1 Text format and information purpose.Table 2.2 Abbreviations of medication categories.Table 2.3 Examples of local and national prescribing guidelines.

      3 Chapter 4Table 4.1 Types of assessment.Table 4.2 HEADSS.Table 4.3 How to communicate effectively using the SBAR tool in a medicine’s mana...

      4 Chapter 5Table 5.1 Pharmacokinetics of paracetamol.Table 5.2 Factors that affect absorption of drugs.Table 5.3 Examples of opioid by receptor binding.Table 5.4 Narrow Therapeutic Index examples.

      5 Chapter 6Table 6.1 Different types of oral solid dosage forms.Table 6.2 Different routes of parenteral injection.Table 6.3 Excipients with a known potential to cause harm in CYP.Table 6.4 Locations of the main types of enteral feeding tubes.Table 6.5 Merits and drawbacks of different formulations for administration via...

      6 Chapter 7Table 7.1 The layers of the heart.Table 7.2 Pharmacokinetics of statins.Table 7.3 Cautions or considerations for all statins.Table 7.4 Warfarin versus Aspirin ADME.Table 7.5 Contraindication and side effects of ACE inhibitors.Table 7.6 Four main actions of cardiovascular system drugs.Table 7.7 Vaughan‐Williams classification.Table 7.8 Sub‐classifications of beta blockers.Table 7.9 Dose‐dependent dopamine hydrochloride actions.Table 7.10 Table of inotropic actions.

      7 Chapter 8Table 8.1 Furosemide dosage for CYP.Table 8.2 Calcineurin inhibitors monitoring and side effects.Table 8.3 Phosphate binders and their related pharmacology.Table 8.4 Vitamin D supplements and their related pharmacology.Table 8.5 Potassium binders and their related pharmacology.Table 8.6 Potassium supplements and their related pharmacology.Table 8.7 Bicarbonate supplementation and the related pharmacology.Table 8.8 Common ACE inhibitors used for CYP, monitoring and side effects.

      8 Chapter 9Table 9.1 Some common terminology used in relation to the endocrine system.Table 9.2 Medications used in endocrine disorders affecting growth.Table 9.3 Aromatase inhibitors or anti‐androgenic drugs.Table 9.4 Medications used in disorders of the adrenal glands.Table 9.5 Comparison of the potency of various corticosteroid medications where...Table 9.6 Medications used in the treatment of diabetes are discussed.Table 9.7 Comparison of absorption rates and length of action of insulin types.

      9 Chapter 10Table 10.1 Classes of asthma medication.Table 10.2 The management of acute asthma in children 5 years and over.Table 10.3 Treatment of croup.Table 10.4 Oxygen delivery methods in children.Table 10.5 Beta2 agonists.Table 10.6 Ipratropium bromide.Table 10.7 Montelukast.Table 10.8 Aminophylline and theophyline.Table 10.9 Oral steroids.

      10 Chapter 11Table 11.1 GOR and GORD clinical manifestations.Table 11.2 Side effects of PPIs.Table 11.3 Risks associated with medication administration via an enteral t...Table 11.4 Impact of a blocked enteral tube on the CYP and their family.Table 11.5 Legal aspects of medication administration via enteral tubes.Table 11.6 Investigations required to confirm Crohn’s disease.

      11 Chapter 12Table 12.1 Treating convulsive status epilepticus.

      12 Chapter 13Table 13.1 T cells.Table 13.2 Examples of inactivated vaccines.Table 13.3 The properties of three inactivated vaccines.Table 13.4 Immunisation schedule.

      13 Chapter 14Table 14.1 Severity of eczema.Table 14.2 Types of psoriasis.

      14 Chapter 15Table 15.1 Symptoms associated with hyponatraemia.Table 15.2 Risk factors for developing antidepressant‐related hyponatraemia....Table 15.3 Symptoms of serotonin syndrome.

      15 Chapter 16Table 16.1 Commonly used alkylating drugs in CYP cancer.Table 16.2 Commonly used antimetabolites in CYP cancer care.Table 16.3 Commonly used anthracyclines and other antibiotics in CYP cancer care.Table 16.4 Commonly used vinca alkaloids in CYP cancer.Table 16.5 Properties of cyclophosphamide.Table 16.6 Examples of monoclonal antibodies.Table 16.7 Properties of rituximab as a monoclonal antibody.Table 16.8 Other checkpoint inhibitors.Table 16.9 Indications for use of transplant.Table 16.10 Examples of adoptive cell transfer drugs.Table 16.11 Examples of cytokines.Table 16.12 Side effects of immunotherapy.Table 16.13 Examples of corticosteroid use in cancer.Table 16.14 Examples of corticosteroid.Table 16.15 Dexamethasone.Table 16.16 Side effects of corticosteroids.

      16 Chapter 17Table 17.1 Examples of non‐opioids and non‐steroidal anti‐inflammatory drugs (NSA...Table 17.2 Examples of opioids and the associated pharmacokinetics, pharmacodynam...Table 17.3 Dosages and administration time for EMLA cream.

      17 Chapter 18Table 18.1 Commonly used penicillins in CYP.Table 18.2 Commonly used cephalosporins in CYP.Table 18.3 Commonly used aminoglycosides in CYP.Table 18.4 Commonly used tetracyclines in CYP.Table 18.5 Commonly used macrolides in CYP.Table 18.6 Commonly used fluroquinolones in CYP.Table 18.7 The properties of phenoxymethylpenicillin (Penicillin V).Table 18.8 Commonly used anti‐herpes medications in CYP.Table 18.9 Antiviral medications licensed for the treatment of HIV in CYP by drug...Table 18.10 Commonly used influenze medications in CYP.Table 18.11 The properties of Aciclovir.Table 18.12 Commonly used azole antifungal medications in CYP.Table 18.13 Commonly used polyenes antifungal medications in CYP.Table 18.14 Commonly used echinocandin antifungal medications in CYP.Table 18.15 The properties of Fluconazole.Table 18.16 Commonly used antimalarials in CYP.Table 18.17 Commonly used antiprotozoal medications in CYP.Table 18.18 The properties of metronidazole.

      18 Chapter 19Table 19.1 Classification of adverse drug reactions.Table 19.2 The Five As of drug‐induced adverse events.

      List of Illustrations

      1 Chapter 1Figure 1.1 The key elements associated with social prescribing (NHS, 2020). ...

      2 Chapter 2Figure 2.1 Drug‐class monographs.Figure 2.2 Contraindication and class monograph.Figure 2.3 Home page of MIMS online (www.mims.co.uk/).Figure 2.4 How to determine if a drug or device can be prescribed on the NHS...

      3 Chapter 3Figure 3.1 Dummy gelatine capsules in order of size compared with typical sw...Figure 3.2 Comic poster teaching children to swallow tablets.

      4 Chapter 4Figure 4.1 Five moments of medication safety. Figure 4.2 Team around the patient in clinical practice.

      5 Chapter 5Figure 5.1 An integration of ADME and the routes of administration.Figure 5.2 A visual representation of cell membrane layers.Figure 5.3 Medication delivery to infant during gestation.Figure 5.4 Hepatic first pass metabolism.Figure 5.5 Pharmacokinetics (ADME) and the main anatomical structures/physio...Figure 5.6 Therapeutic range.Figure 5.7 Paracetamol and ibuprofen maintain therapeutic level.Figure 5.8 The step‐by‐step process of s second messenger system....Figure 5.9 Step‐by‐step receptor‐mediated ion channel.

      6 Chapter 6Figure 6.1 Stepwise approach for selecting appropriate medications for CYP....

      7 Chapter 7Figure 7.1 Gross anatomy and blood flow of the heart.Figure 7.2 QRS/QT type 1 affects.Figure 7.3 Areas of parasympathetic and sympathetic innervation.Figure 7.4 Sympathetic