Anti-Aging Therapeutics Volume XV. A4M American Academy. Читать онлайн. Newlib. NEWLIB.NET

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and both the amount of physical activity and the patients' satisfaction with their level of physical activity improved after 12 months (P < 0.001). In conclusion, GH replacement therapy, in previously untreated adults with GHD, produces significant decreases in the use of healthcare resources, which are correlated with improvements in QoL.

      CONCLUDING REMARKS

      Repeatedly since the genesis of the anti-aging medical movement in 1991, the media has sought to demonize the use of hormone replacement therapies in healthy but deficient adults. Relying on partisan – and often misinformed – critics, the media fuel and encourage hysteria among the public, which thereby results in a climate of misguided federal and state actions that seek to restrict these safe, proven, life-enhancing therapies.

      Attempts to criminalize the practice of medicine where variations to State Board-favored traditional care threaten the continued advancement of innovative medicine. In these situations, there are no injured patients and no victims yet criminal proceedings are waged against progressive health professionals. State officials abuse their authority in recasting minor administrative issues as criminal acts; this is unjust and may be considered as criminal abuse of their publicly elected positions. Sensationalization by media confuses the public, with false allegations suggesting that HRT in clinically documented cases of adult deficiency syndromes equates to the abuse of performance-enhancing anabolic steroids.

      The American Academy of Anti-Aging Medicine (A4M) is resolute in defending the rights of the patient working in conjunction with their physician in choosing any and all justifiable therapies, drugs and interventions which can be shown to improve either the quality or duration of the human lifespan or the form and function of the individual's physiology in order to achieve greater vitality and health at every age. It is in fact the physician's duty to act as an advocate for the patient's right to obtain the full lawful measure of scientific medical therapeutics necessary for optimum health and personal freedom of choice in healthcare.

      The observation by George Orwell (1903-1950), English novelist, in the prognostic classic novel 1984, that: “War is peace. Freedom is slavery. Ignorance is strength” predicts that In a world where lies are supported by the establishment, to stand firm for truth is a dangerous and revolutionary action. Physicians of conscience and good will must unite to take back the future – or all freedoms, including freedom of choice in healthcare – will be lost forever.

      APPENDIX A. LITERATURE REVIEW

      This section presents a selection of published peer-reviewed studies that document the life-enhancing and/or life extending benefits of HRT in aging adults. For further references, see the A4M’s White Paper “Guidance for Physicians on Hormone Replacement Therapy”; A4M, May 2007; available at: http://www.worldhealth.net/white-papers-official-statements/

      HGH

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      Adamopoulos S et al. Growth hormone administration reduces circulating proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure secondary to idiopathic dilated cardiomyopathy. Am Heart J 2002 Aug;144(2):359-64

      Aimaretti G et al. Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency.Clin Endocrinol (Oxf). 2003 Jul; 59(1):56-61

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      Boguszewski CL, Meister LH, Zaninelli DC, Radominski RB. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. Eur J Endocrinol. 2005;152:67-75.

      Bohdanowicz-Pawlak A et al. Risk factors of cardiovascular disease in GH-deficient adults with hypopituitarism: a preliminary report. Med Sci Monit. 2006 Feb; 12(2):CR75-80.

      Borson-Chazot F. et al. Decrease in Carotid Intima-Media Thickness after One Year Growth Hormone (GH) Treatment in Adults with GH Deficiency J Clin Endocrinol Metab 84: 1329–1333, 1999

      Branski LK et al. Randomized Controlled Trial to Determine the Efficacy of Long-Term Growth Hormone Treatment in Severely Burned Children., Ann Surg. 2009 Sep 2

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      Cappola AR et al. Association of IGF-I levels with muscle strength and mobility in older women. J Clin Endocrinol Metab 2001 Sep; 86(9):4139-46

      Cappola et al. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women JCEM, 2003 May; 88(5):2019-25.

      Cenci MC, Soares DV, Spina LD, Brasil RR, Lobo PM, Michmacher E, Vaisman M, Boguszewski CL, Conceição FL. Comparison of two dose regimens of growth hormone (GH) with different target IGF-1 levels on glucose metabolism, lipid profile, cardiovascular function and anthropometric parameters in gh-deficient adults. Growth Horm IGF Res. 2012;22:116-121.

      Chan et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science Vol 279 January 1998

      Cherbonnier C et al. Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-kappaB activity. Br J Cancer.