Anti-Aging Therapeutics Volume XIV. A4M American Academy. Читать онлайн. Newlib. NEWLIB.NET

Автор: A4M American Academy
Издательство: Ingram
Серия:
Жанр произведения: Медицина
Год издания: 0
isbn: 9781934715109
Скачать книгу
physiologic role; this does not mean that such doses are safe or appropriate for long-term use. Secondly, urinary iodine is not expected to reach a steady state for several months after iodine ingestion is raised or lowered. Therefore a 24-hour urine collection post iodine-loading dose would not reflect iodine status. Finally, the toxicology of iodine is well established. Some can manifest latent antithyroid antibodies when raising iodine intake by even a few hundred micrograms.

      Whilst it is plausible that Lodoral® can help with fatigue, as many doctors have reported, this is hardly an argument to justify its use since iodine has long been known to cause stimulant like side effects early on in its toxicity. It is certainly possible to hear patients claim positive benefits from a treatment, and a clinician may not see side effects even with a high number of observations. Statistically, one could prescribe lovastatin to 6490 patients prior to seeing a single case of hepatocellular damage. Yet we take it as a given that liver damage is a risk patients face when taking statin drugs and we factor such risk into the risk/benefit assessment prior to prescribing. The risks with mega-dose iodine are quite clear. The benefits are vague and nebulous at best and there is no evidence to support putting a patient at risk for life-long thyroid disease or possibly lethal thyroid storm for the poorly substantiated possible benefits claimed by its proponents.

      Relevance of Iodine to the Integrative Physician

      In the context of discussions on diet and micronutrient intake, physicians should counsel patients on optimal iodine intake. Since iodine is readily absorbed, human iodine requirements are not variable and its status is predictable based on intake. Iodine assessment is not a useful part of medical screening due to its poor reliability. Since nearly all Americans consume sodium well in excess of 2500 mg daily and since processed foods are made with non-iodized salt, patients should be advised to minimize their salt intake from restaurant foods and pre-made groceries. Instead, their prime sodium intake should be from home cooked foods made with conservative use of iodized table salt or iodized sea salt. Along with iodized salt, consuming a variety of fruits, vegetables, meats, sea foods and grains can provide a basal amount of iodine. Additionally, pregnant and lactating women should be advised to consume a multivitamin containing 50-100 μg of iodine daily.

      REFERENCES

      1.Rosenfeld L. Discovery and early uses of iodine. Journal of Chemical Education. 2000;77:984.

      2.Braverman LE, Utiger RD, eds. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text. 8th ed. Philadelphia, Pa: Lippincott, Williams & Wilkins;2000.

      3.Kelly FC. Iodine in medicine and pharmacy since its discovery – 1811-1961. Proc R Soc Med. 1961;54:831-836.

      4.Wilford J. Neanderthal or cretin. A debate over iodine. New York Times. December 1, 1998.

      5.Preedy V, Burrow G, Watson R, eds. Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological, and Therapeutic Aspects. Academic Press; 2009. Kindle Edition. Location 2769.

      6.Preedy V, Burrow G, Watson R, eds. Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological, and Therapeutic Aspects. Academic Press; 2009. Kindle Edition. Location 2740.

      7.Preedy V, Burrow G, Watson R, eds. Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological, and Therapeutic Aspects. Academic Press; 2009. Kindle Edition. Location 2810.

      8.Stipanuk MH. Biochemical, Physiological & Molecular Aspects of Human Nutrition. 1st ed. Elsevier Health Sciences;2000:763.

      9.Eng PH, Cardona GR, Fang SL, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999;140:3404-3410.

      10.Stipanuk MH. Biochemical, Physiological & Molecular Aspects of Human Nutrition. 1st ed. Elsevier Health Sciences;2000:772.

      11.Stipanuk MH. Biochemical, Physiological & Molecular Aspects of Human Nutrition. 1st ed. Elsevier Health Sciences;2000:764.

      12.Preedy V, Burrow G, Watson R, eds. Comprehensive Handbook of Iodine Nutritional, Biochemical, Pathological, and Therapeutic Aspects. Academic Press; 2009. Kindle Edition. Location 2450.

      13.Stipanuk MH. Biochemical, Physiological & Molecular Aspects of Human Nutrition. 1st ed. Elsevier Health Sciences;2000:762.

      14.Stipanuk MH. Biochemical, Physiological & Molecular Aspects of Human Nutrition. 1st ed. Elsevier Health Sciences;2000:779.

      15.Zagrodzki P, Szmigiel H, Ratajczak R, Szybinski Z, Zachwieja Z. The role of selenium in iodine metabolism in children with goiter. Environ Health Perspect. 2000;108:67-71.

      16.Vanderpas J. Nutritional epidemiology and thyroid hormone metabolism. Annu Rev Nutr. 2006;26:293-322.

      17.Pearce EN, Pino S, He X, Bazrafshan HR, Lee SL, Braverman LE. Sources of dietary iodine: bread, cows' milk, and infant formula in the Boston area. J Clin Endocrinol Metab. 2004;89:3421-3424.

      18.Müssig K, Thamer C, Bares R, Lipp HP, Häring HU, Gallwitz B. Iodine-induced thyrotoxicosis after ingestion of kelp-containing tea. J Gen Intern Med. 2006;21:C11-14.

      19.Sumar S, Ismail H. Iodine in food and health. Nutrition & Food Science. 1997;97:175-183.

      20.Gomo ZA, Allain TJ, Matenga JA, Ndemere B, Wilson A, Urdal P. Urinary iodine concentrations and thyroid function in adult Zimbabweans during a period of transition in iodine status. Am J Clin Nutr. 1999;70:888-891.

      21.Nyiri W, Jannitti M. About the fate of free iodine upon application to the unbroken animal skin. J Pharmacol Exp Ther. 1932;45:85-107.

      22.Biskind MS. Penetration through tissue of iodine in different solvents. Proc Soc Exp Biol Med. 1932;30:35-37.

      23.Hollowell JG, Staehling NW, Hannon WH, et al. Iodine nutrition in the United States. Trends and public health implications: iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-1974 and 1988-1994). J Clin Endocrinol Metab. 1998;83:3401-3408.

      24.Caldwell KL, Jones R, Hollowell JG. Urinary iodine concentration: United States National Health and Nutrition Examination Survey 2001-2002. Thyroid. 2005;15:692-699.

      25.Block SS. Disinfection, sterilization, and preservation. 5th ed. Hagerstwon, MD: Lippincott Williams & Wilkins; 2000.

      26.Toxicological Profile for Iodine. Agency for Toxic Substances and Disease Registry Web site. http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=479&tid=85. Accessed February 9, 2012.

      27.National Research Council. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press; 2001:258-289.

      ABOUT THE AUTHOR

      Dr. Alan Christianson was a member of the first graduating class of the Southwest College of Naturopathic Medicine (Tempe, AZ USA). A specialist in thyroid disorders, Dr. Christianson is the author of the “Complete Idiot’s Guide to Thyroid Disease” and wrote the chapters on Hypothyroidism and Hyperthyroidism for the 9th edition of the “Textbook of Natural Medicine.”

      Chapter 7

      Assessment of Biological Aging & Treatment of Metabolic Inflammatory Diseases

      Nick Delgado Ph.D., CHT

      Director, Ultimate Medical Research; Founder, The Delgado Protocol

      ABSTRACT

      This paper reviews various treatments and interventional therapies that modulate the mitochondria metabolic breakdown or inflammation and the clinical protocols known to stimulate repair, stem cells release and cellular oxygenation and regeneration.

      INTRODUCTION

      Today,