Theophrastus speaks of a poison which could be moderated in such a manner as to have effect in two or three months, or at the end of a year, or two years; and he remarks that the death, the more lingering it was, became the more miserable. This poison was prepared from aconitum, a plant which, on that account, people were forbidden to have in their possession, under pain of capital punishment108. He relates also, that Thrasyas had discovered a method of preparing from other plants a poison which, given in small doses of a drachm, occasioned an easy but certain death, without any pain, and which could be kept back for a long time without causing weakness or corruption. This Thrasyas, whose scholar Alexias carried the art still further, was a native of Mantinea, a city in Arcadia, and is celebrated by Theophrastus on account of his abilities, and particularly his knowledge of botany; but those are mistaken who ascribe to him the discovery of secret poison.
This poison was much used at Rome about two hundred years before the Christian æra. As several persons of distinction died the same year at that period, and of the like distemper, an inquiry being made into the cause, a maid-servant gave evidence against some ladies of the first families, who, she said, prepared and distributed poison; and above a hundred and fifty of them were convicted and punished109. As so many had learnt this destructive art, it could not be suppressed; and we find sufficient proofs in the Roman history that it was continually preserved. Sejanus caused such a secret poison to be administered by an eunuch to Drusus, who gradually declined afterwards, as by a consumptive disorder, and at length died110. Agrippina, being desirous of getting rid of Claudius, but not daring to despatch him suddenly, and yet wishing not to leave him sufficient time to make new regulations respecting the succession to the throne, made choice of a poison which should deprive him of his reason, and gradually consume him. This she caused to be prepared by an expert poisoner, named Locusta, who had been condemned to death for her infamous actions, but saved that she might be employed as a state engine. The poison was given to the emperor in a dish of mushrooms; but as, on account of his irregular manner of living, it did not produce the desired effect, it was assisted by some of a stronger nature111. This Locusta prepared also the poison with which Nero despatched Britannicus, the son of Agrippina, whom his father Claudius wished to succeed him on the throne. As this poison occasioned only a dysentery, and was too slow in its operation, the emperor compelled Locusta by blows, and by threatening her with death, to prepare in his presence one more powerful. It was first tried on a kid; but as the animal did not die till the end of five hours, she boiled it a little longer, until it instantaneously killed a pig to which it had been given, and this poison despatched Britannicus as soon as he had tasted it112. For this service the emperor pardoned Locusta, rewarded her liberally, and gave her pupils whom she was to instruct in her art, in order that it might not be lost.
The art of preparing this poison must have been well understood also at Carthage. When M. Attilius Regulus, the Roman general, who had been taken by the Carthaginians, was sent to Rome to propose to the senate that the Carthaginian prisoners might be restored in exchange for him, he prevented this negotiation, because he knew that a poison had been administered to him, by which the state would soon be deprived of his services. He returned, therefore, to Carthage, in compliance with the promise he had made to the enemy, who put him to death with the most exquisite torture113.
All these poisons were prepared from plants, particularly aconite, hemlock and poppy, or extracted from animal substances. Among those made from the latter, none is more remarkable than that supplied by the sea-hare, lepus marinus, with which, as Philostratus says114, Titus was despatched by Domitian. Without here attempting to define the substances employed by the ancients to compose their poisons, I shall only observe, that the lepus marinus, the terrible effects of which are expressly mentioned by Dioscorides, Galen, Nicander, Aëtius, Ælian115, Pliny116, and others, is that animal called at present in the Linnæan system Aplysia depilans117, as Rondelet conjectured, and has been since fully proved by Bohadsch118. This animal poison however seems to have been seldom used, as it easily betrays itself by some peculiar symptoms. It appears that it was not known to Aristotle, at least he makes no mention of it119. With the far stronger, and now common mineral poisons the ancients were not acquainted; for their arsenic was what we call orpiment, and not that pernicious metallic oxide which formed the principal ingredient of those secret poisons which in latter times were in France and Italy brought to a diabolical perfection120.
No one was ever more infamous by this art than Tophania, or Toffana, a woman who resided first at Palermo, and afterwards at Naples. She sold those drops, which from her acquired the name of aqua Tophania, aqua della Toffana, and which were called also acquetta di Napoli, or only acquetta; but she distributed her preparation by way of charity to such wives as wished to have other husbands. From four to six drops were sufficient to destroy a man; and it was asserted that the dose could be so proportioned as to operate in a certain time. As she was watched by the government, she fled to an ecclesiastical asylum; and when Keysler was at Naples in 1730, she was then still living, because no one could, or was willing to take away her life, while under that protection. At that time she was visited by many strangers out of curiosity.
In Labat’s Travels through Italy121 we also find some information which may serve still further to illustrate the history of Tophania. She distributed her poison in small glass phials, with this inscription, Manna of St. Nicholas of Bari, and ornamented with the image of the saint. A miraculous oil, employed by folly in the cure of many diseases, drops from the tomb of that saint which is shown at Bari in the kingdom of Naples; and on this account it is dispersed in great abundance under the like name. It was therefore the best appellation which Tophania could give to her poison, because the reputed sanctity of it prevented the custom-house officers from examining it too closely. When the viceroy was informed of this, which I think was in 1709, Tophania fled from one convent to another, but was at length seized and thrown into prison. The clergy raised a loud outcry on account of this violation of ecclesiastical freedom, and endeavoured to excite the people to insurrection. But they were soon appeased on a report being spread that Tophania had confessed she had poisoned all the springs in the city. Being put to the rack, she acknowledged her wickedness, and confessed to having caused the death of not less than 600 persons; named those who had protected her, who were immediately dragged from churches and monasteries; and declared that the day before she had absconded, she had sent two boxes of her manna to Rome, where it was found in the custom-house, but she did not accuse any one of having ordered it. She was afterwards strangled, and to mitigate the archbishop, her body was thrown at night into the area of the convent from which she had been taken. Tophania however was not the only person at Naples who understood the making of this poison; for Keysler says that at the time he was there it was still secretly prepared and much employed.
In the year 1659, under the government of Pope Alexander VII., it was observed at Rome that many young married women were left widows, and that many husbands died when they became disagreeable to their wives. Several of the clergy declared also, that for some time past various persons had acknowledged at confession that they had been guilty of poisoning. As the government employed the utmost vigilance to discover these poisoners, suspicion fell upon a society of young married women, whose president appeared to be an old woman who pretended to foretell future events, and who had often predicted very exactly many deaths to persons who had cause to wish for them. To ascertain the truth, a crafty female, given out to be a person of considerable distinction,