21 14 Toward Precision Medicine: Epigenetic Alterations in Human Melanoma
22 15 Currents Trends and Future Perspectives in Our Epigenetic Signatures: What a Diet Can Trigger
26 19 Epigenetic Regulation of Sex Determination and Toxicity in Nonmammalian Vertebrates
28 Index
List of Illustrations
1 Chapter 2Figure 2.1 Tissue-specific miRNAs in mammals. Human....
2 Chapter 3Figure 3.1 Schematic illustration of extracellular vesicles (EVs....Figure 3.2 Gel electrophoresis of mouse liver total....Figure 3.3 Canonical miRNA biogenesis pathway....Figure 3.5 Horizontal gene transfer mediated by EVs....Figure 3.6 (a) Schematic representation of the engineered....Figure 3.7 Schematic representation of toxicity testing using....Figure 3.8 Evaluation of EVs using NanoSight. Serum....Figure 3.9 Representative H&E micrographs of....Figure 3.10 Differentially expressed EV-associated miRNAs. Individual....
3 Chapter 4Figure 4.1 Major routes of exposure for heavy....Figure 4.2 Simplified overview of miRNA biogenesis and....Figure 4.3 Differential expression map of circulating miRNAs....Figure 4.4 Differential expression map of circulating miRNAs....
4 Chapter 6Figure 6.1 Comparison of innate immune system genes....Figure 6.2 Regulation of innate immune system responses....
5 Chapter 7Figure 7.1 Xenobiotic exposure to the disease development....Figure 7.2 Steps involved in the transcriptome analysis....Figure 7.3 Cytotoxicity and DGE profile in an....Figure 7.4 Biological functions enriched in response to....Figure 7.5 Crystalline silica-induced lung toxicity and....Figure 7.6 Biological functions enriched in response to....
6 Chapter 8Figure 8.1 Categories of the graph. a Undirected....Figure 8.2 Alterations in protein-protein interactions in....Figure 8.3 a OncoPPi network containing 83 lung....Figure 8.4 Construction and analysis of a co....Figure 8.5 Gene regulatory elements and the GRN....Figure 8.6 There are two categories of metabolic....Figure 8.7 Proteins associated with the same disease....Figure 8.7 Disease association of TSGs. a Bi....
7 Chapter 10Figure 10.1 The potential roles of epigenetic modifications....Figure 10.2 A schematic illustration of how low....
8 Chapter 13Figure 13.1 The SMYD protein family. S, S....Figure 13.1 SMYD proteins involved in cancer-promoting....
9 Chapter 14Figure 14.1 Estimated age-standardized incidence rates of....Figure 14.2 Post-translational changes in histones N....Figure 14.3 Classification of main types of non....Figure 14.4 Main molecular events in melanoma progression....
10 Chapter 15Figure 15.1 From nutritional factors to phenotype. The....Figure 15.2 The complex interrelationship between....Figure 15.3 The dynamics of epigenetics over generations....Figure 15.4 The direct and indirect consequences of....Figure 15.5 The role of diet in folic....Figure 15.6 The transgenerational effect of nutrients. The....Figure 15.7 The role of breastfeeding in the....Figure 15.8 The number of studies focused on....
11 Chapter 16Figure 16.1 General structure of an OP. R....Figure 16.2 (A) Dialkyl phosphate general formula; (B....Figure 16.3 DAP structures and pKa. Upper row....Figure 16.4 Toxic effects observed in human populations....Figure 16.5 Genetic and epigenetic effects of OP....
12 Chapter 17Figure 17.1 Genetic, epigenetic, and anatomical factors involved....Figure 17.2 The role of estrogen receptors (ESRs....
13 Chapter 18Figure 18.1 Experimental approach. DNA and RNA were....Figure 18.2 Differentially methylated bases (DMBs) and clusters....Figure 18.3 CpG coverage by BisDNA-seq. Reads....Figure 18.4 Epigenomic features of DNA methylation in....Figure 18.5 Increased gene methylation in arsenic-transformed....Figure 18.6 Increased methylation of CpG islands and....Figure 18.7 CpG sites for the validation of....Figure 18.8 Validation of BisDNA-seq methylation CpG....Figure 18.9 Association of gene methylation and expression....Figure 18.10 Specific genes with an inverse association....Figure 18.11 Genes showing an inverse association between....
14 Chapter 19Figure 19.1 Major epigenetic machineries. (A) DNA methylation....Figure 19.2 Sex determining cascades in non-mammalian....Figure 19.3 Modes of sex reversal among teleost....Figure 19.4 Sex reversal and inheritance of DNA....Figure 19.5 Phylogenetic relationship between reptiles and sex....Figure 19.6 Temperature-dependent regulation of dmrt1 in....Figure 19.7 Temperature-induced sex reversal in the....Figure 19.8 Epigenetic regulation of dmrt1 expression in....
15 Chapter 20Figure 20.1 Different -omics approaches applied in zebrafish....Figure 20.2 General outcomes of nanoparticle toxicity in....Figure 20.3 Major epigenetic alterations identified in the....Figure 20.4 Key pathways of neuronal toxicity induced....Figure 20.5 General routes of immunotoxicity....Figure 20.6 Reproductive toxicity outcomes identified....
List of Tables
1 Chapter 2Table 2.1 Human studies on environmental toxicant-induced...
2 Chapter 3Table 3.1 Main characteristics of exosomes...
3 Chapter 3Table 3.2 Summary of exosomal proteins for early tumor diagnosis.
4 Chapter 3Table 3.3 Summary of exosomal miRNAs for early tumor diagnosis.
5 Chapter 4Table 4.1 Description of biomarker subtypes.
6 Chapter 6Table 6.1 Comparative Toxicogenomics Database’s top...
7 Chapter 6Table 6.2 Immune system pathways perturbed by exposure...
8 Chapter 6Table 6.3 Danio rerio macrophage and neutrophil specific....
9 Chapter 6Table 6.4 miRNAs associated with the innate immune...
10 Chapter 6Table 6.5 Arsenic perturbation of miRNAs associated...
11 Chapter 7Table 7.1 Fold changes in expressions of genes...
12 Chapter 7Table 7.2 Fold changes in expressions of genes...
13 Chapter