Table of Contents
1 Cover
6 Part I: Biological Basis of the Peripheral T‐cell Lymphomas 1 The Fundamentals of T‐cell Lymphocyte Biology Introduction General View of the Differentiation and Function of T Lymphocytes The T‐cell System as a Frame for Peripheral T‐cell Lymphoma: Taking Plasticity into Account Must Reads References 2 Mechanisms of T‐cell Lymphomagenesis Introduction Oncogenic Events in the Transformation of T or Natural Killer Cells Conclusion Acknowledgement Must Reads References 3 Epigenetics of T‐cell Lymphoma Introduction Epigenetic Pathways Altered in T‐cell Lymphoma Epigenetic Changes Within Specific T‐cell Lymphoma Subtypes Established and Emerging Drugs Targeting the T‐cell Lymphoma Epigenome Combination Therapies Involving Epigenetic Targeting Agents Future Directions Must Reads References 4 Animal Models of T‐cell Lymphoma Introduction Angioimmunoblastic T‐cell Lymphoma Anaplastic Large T‐cell Lymphoma Human T‐cell Lymphotropic Virus Type 1 Adult T‐cell Leukemia/Lymphoma Cutaneous T‐cell Lymphoma Enteropathy‐associated T‐cell Lymphoma Conclusion Must Reads References
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Part II: Epidemiology and Classification of the PTCL
5 Geographic Distribution of the Peripheral T‐cell Lymphomas
Historical Perspective
Epidemiology
Conclusion
Must Reads
References
5.A 2017 World Health Organization Classification of Mature T- and NK-cell Neoplasms
6 Classification of the Peripheral T‐cell Lymphomas
Introduction
Angioimmunoblastic T‐cell Lymphoma and Other Nodal Lymphomas of T follicular Helper Cell Origin
Peripheral T‐cell Lymphoma Not Otherwise Specified
Anaplastic Large‐cell Lymphomas
Adult T‐cell Leukemia/Lymphoma
Intestinal T‐cell Lymphomas
Hepatosplenic T‐cell Lymphoma
Mycosis Fungoides
Sézary Syndrome
Primary Cutaneous CD30‐positive T‐cell Lymphoproliferative Disorders
Primary Cutaneous Gamma–Delta T‐cell Lymphoma
Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T‐cell Lymphoma (Provisional)
Primary Cutaneous CD4+ Small/Medium T‐Cell Lymphoproliferative Disorder (Provisional)
Primary Cutaneous Acral CD8+ T‐cell Lymphoma (Provisional)
Large Granular Lymphocytic Leukemia
T‐cell Prolymphocytic Leukemia
NK‐cell Lymphomas
Must Reads
References
7 Molecular Classification of the Peripheral T‐cell Lymphomas
Introduction
T‐cell Development and Activation: An Overview
T‐cell Receptor Signaling
Derivation of Diagnostic Signatures for Molecular Classification