Table of Contents
1 Cover
2 Preface What’s New Principles Taught in Two Distinct, but Integrated Volumes
6 PART I: The Science of Virology 1 Foundations Luria’s Credo Viruses Defined Why We Study Viruses Virus Prehistory Discovery of Viruses The Defining Properties of Viruses Cataloging Animal Viruses A Common Strategy for Viral Propagation Perspectives References 2 The Infectious Cycle Introduction The Infectious Cycle Viral Pathogenesis Overcoming Host Defenses Cultivation of Viruses Assay of Viruses Viral Reproduction: the Burst Concept The One-Step Growth Cycle Global Analysis Single-Cell Virology Perspectives References
7
PART II: Molecular Biology
3 Genomes and Genetics
Introduction
Genome Principles and the Baltimore System
Structure and Complexity of Viral Genomes
What Do Viral Genomes Look Like?
Coding Strategies
What Can Viral Sequences Tell Us?
The “Big and Small” of Viral Genomes: Does Size Matter?
The Origin of Viral Genomes
Genetic Analysis of Viruses
Perspectives
References
4 Structure
Introduction
Building a Protective Coat
Packaging the Nucleic Acid Genome
Viruses with Envelopes
Large Viruses with Multiple Structural Elements
Other Components of Virions
Mechanical Properties of Virus Particles
Perspectives
References
5 Attachment and Entry
Introduction
Attachment of Virus Particles to Cells
Entry into Cells
Intracellular Trafficking and Uncoating
Import of Viral Genomes into the Nucleus
Perspectives
References
6 Synthesis of RNA from RNA Templates
Introduction
The Nature of the RNA Template
The RNA Synthesis Machinery
Mechanisms of RNA Synthesis
Paradigms for Viral RNA Synthesis
Origins of Diversity in RNA Virus Genomes
Perspectives
References
7 Synthesis of RNA from DNA Templates
Introduction
Transcription by RNA Polymerase II
Transcription of Viral DNA Templates by the Cellular Machinery Alone
Viral