Oral Cells and Tissues. Philias R. Garant

      

      Oral Cells and Tissues

      Philias R. Garant, DMD Professor Department of Periodontics School of Dental Medicine State University of New York at Stony Brook Stony Brook, New York

       Library of Congress Cataloging-in-Publication Data

      Garant, Philias R.

       Oral cells and tissues / Philias R. Garant.

       p. ; cm.

      Includes bibliographical references.

       ISBN 0-86715-429-2

       1. Teeth—Cytology. 2. Mouth—Cytology. 3. Oral mucosa—Cytology.

       [DNLM: 1. Stomatognathic System—anatomy & histology. 2.

      Stomatognathic System—embryology. WU 101 G212o 2003] I. Title.

       QP88.6.G37 2003

       611'.0181—dc21

       2003006003

      © 2003 Quintessence Publishing Co, Inc

      Quintessence Publishing Co, Inc

      551 Kimberly Drive

      Carol Stream, Illinois 60188

      www.quintpub.com

      Editor: Arinne Dickson

      Internal design and production: Patrick Penney

      Cover design: Dawn Hartman

      All rights reserved. This book or any part thereof may not be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, or otherwise, without prior written permission of the publisher.

      Printed in Canada

       To my wife, Jeanne

       Table of Contents

Preface

1 Early Tooth Development

Role of the Neural Crest

Development of the Dental Lamina, Enamel Organ, and Dental Papilla

Epithelial-Ectomesenchymal Morphogenetic Regulation of Odontogenesis

Growth and Differentiation Factors That Regulate Tooth Formation

Establishing Coronal Form (Cusp Formation)

Basic Science Correlations

Clinical Correlation: The Human Dentition

2 Dentin

Differentiation of Odontoblasts

Secretion of Dentin Matrix

Structure of Mature Secretory Odontoblasts

Composition of the Dentin Matrix

Mineralization of Mantle and Circumpulpal Dentin

Structure of the Odontoblastic Process and Dentinal Tubules

Formation of Intertubular and Peritubular Dentin

Transport Across the Odontoblastic Layer

Innervation of Dentin and Mechanisms of Pain Sensation

Supply of Blood to the Pulp

Cells and Extracellular Matrix of the Dental Pulp

Basic Science Correlation: The Secretory Pathway

Clinical Correlations

3 Enamel

Differentiation of the Enamel Organ

Structure of Secretion-Stage Ameloblasts

Biology of the Enamel Matrix

Location and Expression of Amelogenin, Ameloblastin, and Tuftelin Genes

Mineralization of the Enamel Matrix

Structure of Transition-Stage Ameloblasts