Promoting Wellness
Beyond Hormone
Therapy
OPTIONS FOR PROSTATE CANCER PATIENTS
MARK A. MOYAD, MD, MPH
SECOND EDITION
This book is dedicated to my dad and doctor, Robert Moyad. He taught me what it means to put patients first and what it means to be a good husband and father.
It is also dedicated to the individuals—Epstein, Jenkins, Pokempner, and Thompson—who invest in the dream and allow me to make a difference one starfish at a time.
Another group that deserves credit are all of the oncologists, urologists, and other healthcare professionals from around the world whom I consulted with during the preparation of this book. I cannot thank you enough for your passion and dedication to your patients, your overall guidance, your objective critiques of the manuscript, and your friendship.
And finally, this book is dedicated to the advocates, advocacy groups, healthcare professionals, patients, and their families who have battled and are still fighting prostate cancer.
Second edition © 2013 Mark A. Moyad
All rights reserved. No portion of this book may be reproduced in any manner without the express written consent of the publisher, except in the case of brief excerpts in critical reviews or articles.
All inquiries should be addressed to:
Spry Publishing LLC
2500 South State Street
Ann Arbor, MI 48104
877-722-2264
E-book ISBN: 9781938170409
Disclaimer: Spry Publishing LLC does not assume responsibility for the contents or opinions expressed herein. Although every precaution is taken to ensure that information is accurate as of the date of publication, differences of opinion exist. The opinions expressed herein are those of the author and do not necessarily reflect the views of the publisher. The information contained in this book is not intended to replace professional advisement of a patient’s doctor prior to beginning or changing the patient’s course of treatment.
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CONTENTS
Questions and Answers to Start
Three Minimal Treatment Options
FDA-Approved Therapies for HRPC
Xgeva, Zometa, and Other Bone-Protecting Drugs
Chapter Six
Zytiga
Chapter Seven
Xtandi
Chapter Eight
Taxotere and Jevtana
Chapter Nine
Alpharadin
Other Considerations
Chapter Ten
Exciting Treatments in the Immediate Pipeline
Chapter Eleven
Preventing and Lessening Side Effects
Chapter Twelve
Diet, Supplements, and Alternative Medicine
Index
WELCOME to the second edition of a unique educational book for individuals dealing with advanced prostate cancer, those with a rising PSA after being on hormone or androgen deprivation therapy (ADT). This book is intended to complement Promoting Wellness for Prostate Cancer Patients, which is currently available and has been circulated around the world for almost a decade. Hormone refractory prostate cancer (HRPC), or as we’re calling it “Beyond Hormonal Therapy,” is a stage of the disease that currently has so many options that it needed its own separate book. Most prostate cancer resources focus on the needs of individuals with localized prostate cancer, leaving a void of information for those men needing further treatment. Our primary goal with this book is to empower you with information and suggestions to assist you in communicating with your doctor and other healthcare professionals while dealing with your cancer. Through that informed communication, you and your physician will select the treatment options that best suit your individual needs.
Section one is a quick review. We start chapter one with questions commonly asked by advanced prostate cancer patients. We’ll discuss how the cancer came to be advanced, what factors affect prognosis, and, generally speaking, what treatments are available. Chapters two and three will cover secondary hormonal treatments and other therapies that are used either before or in addition to the U.S. Food and Drug Administration–approved (FDA-approved) treatments in the section that follows. In chapters four through ten, we will present current cutting-edge treatment information that will allow you to control and hopefully beat this disease. For the upcoming therapies in chapter ten, we’ve focused on those coming in the near future, several months away as opposed to several years away.
Use this book to help you develop questions and understand state-of-the-art treatments. We want this book to give you and the individuals who love and support you the extra knowledge to hit this disease with anything and everything out there. Always